DNA binding proteins explore multiple local configurations during docking via rapid rebinding

Finding the target site and associating in a specific orientation are essential tasks for DNA-binding proteins. In order to make the target search process as efficient as possible, proteins should not only rapidly diffuse to the target site but also dynamically explore multiple local configurations...

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Veröffentlicht in:	Nucleic acids research 2016-09, Vol.44 (17), p.8376-8384
Hauptverfasser:	Ganji, Mahipal, Docter, Margreet, Le Grice, Stuart F J, Abbondanzieri, Elio A
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - metabolism DNA Primers - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Fluorescence Resonance Energy Transfer HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - metabolism Ions Kinetics Macromolecular Substances - metabolism Nucleic Acid Conformation Nucleic Acid Enzymes Nucleotides - metabolism Protein Binding
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