Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

In Alzheimer’s disease (AD), astrocyte properties are modified but their involvement in this pathology is only beginning to be appreciated. The expression of connexins, proteins forming gap junction channels and hemichannels, is increased in astrocytes contacting amyloid plaques in brains of AD pati...

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Veröffentlicht in:	Cell death and differentiation 2016-10, Vol.23 (10), p.1691-1701
Hauptverfasser:	Yi, C, Mei, X, Ezan, P, Mato, S, Matias, I, Giaume, C, Koulakoff, A
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/107 13/51 14 14/34 14/69 64/110 692/699/375 82/29 Adenosine triphosphate Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Apoptosis Astrocytes - metabolism Biochemistry Biomedical and Life Sciences Brain research Calcium - metabolism Cell Biology Cell Communication Cell Cycle Analysis Cell death Cell Membrane Permeability Communication Connexin 43 - metabolism Disease Disease Models, Animal Gap Junctions - metabolism Humans Inflammation - pathology Interdisciplinary aspects Kinases Life Sciences Mice, Inbred C57BL Neurons - metabolism Neurons - pathology Original Paper Presenilin-1 - metabolism Proteins Stem Cells Tumor necrosis factor-TNF
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