A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.34324-34324, Article 34324
Hauptverfasser:	Kim, Beom Seok, Lee, Chang-Hee, Chang, Gyeong-Eon, Cheong, Eunji, Shin, Injae
Format:	Artikel
Sprache:	eng
Schlagworte:	38/1 38/109 38/77 631/92/613 631/92/96 96/1 Astrocytes Depolarization Heart diseases Humanities and Social Sciences multidisciplinary Neural stem cells Neurogenesis Pluripotency Science Science (multidisciplinary) SIRT1 protein Sodium Sodium channels (voltage-gated) Sodium currents Transcription activation Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!