Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins

Enterotoxigenic Escherichia coli (ETEC) causes ∼20% of the acute infectious diarrhea (AID) episodes worldwide, often by producing heat-stable enterotoxins (STs), which are peptides structurally homologous to paracrine hormones of the intestinal guanylate cyclase C (GUCY2C) receptor. While molecular...

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Veröffentlicht in:	Infection and immunity 2016-10, Vol.84 (10), p.3083-3091
Hauptverfasser:	Pattison, Amanda M, Blomain, Erik S, Merlino, Dante J, Wang, Fang, Crissey, Mary Ann S, Kraft, Crystal L, Rappaport, Jeff A, Snook, Adam E, Lynch, John P, Waldman, Scott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Bacterial Infections Bacterial Toxins - metabolism Cyclic GMP - metabolism Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Diarrhea - metabolism Disease Models, Animal Enterotoxigenic Escherichia coli - metabolism Enterotoxigenic Escherichia coli - physiology Enterotoxins - metabolism Enterotoxins - physiology Enzyme-Linked Immunosorbent Assay Escherichia coli Infections - microbiology Escherichia coli Infections - physiopathology Escherichia coli Proteins - metabolism Humans Intestines - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Enterotoxin Receptors, Guanylate Cyclase-Coupled - metabolism Receptors, Peptide - metabolism Signal Transduction - physiology
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