Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus
The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF)....
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| Veröffentlicht in: | International journal of molecular sciences 2016-09, Vol.17 (9), p.1545-1545 |
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| creator | Shigefuku, Ryuta Takahashi, Hideaki Nakano, Hiroyasu Watanabe, Tsunamasa Matsunaga, Kotaro Matsumoto, Nobuyuki Kato, Masaki Morita, Ryo Michikawa, Yousuke Tamura, Tomohiro Hiraishi, Tetsuya Hattori, Nobuhiro Noguchi, Yohei Nakahara, Kazunari Ikeda, Hiroki Ishii, Toshiya Okuse, Chiaki Sase, Shigeru Itoh, Fumio Suzuki, Michihiro |
| description | The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully. |
| doi_str_mv | 10.3390/ijms17091545 |
| format | Article |
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The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully.</description><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms17091545</identifier><identifier>PMID: 27649152</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Adult ; Aged ; Biomarkers - analysis ; Disease Progression ; Female ; Hemodynamics ; Hepacivirus - physiology ; Hepatitis C virus ; Hepatitis C, Chronic - diagnostic imaging ; Hepatitis C, Chronic - metabolism ; Hepatitis C, Chronic - physiopathology ; Hepatitis C, Chronic - virology ; Host-Pathogen Interactions ; Humans ; Liver - blood supply ; Liver - diagnostic imaging ; Liver - physiopathology ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - physiopathology ; Liver Function Tests - methods ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - physiopathology ; Regional Blood Flow - physiology ; ROC Curve ; Tomography, X-Ray Computed - methods ; Xenon</subject><ispartof>International journal of molecular sciences, 2016-09, Vol.17 (9), p.1545-1545</ispartof><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8fee5f3d0a6caf27b9d9d0e9193935adcda32f3934dfe16796beec10a50fa4363</citedby><cites>FETCH-LOGICAL-c417t-8fee5f3d0a6caf27b9d9d0e9193935adcda32f3934dfe16796beec10a50fa4363</cites><orcidid>0000-0002-6738-4382 ; 0000-0002-0915-030X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037819/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037819/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27649152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shigefuku, Ryuta</creatorcontrib><creatorcontrib>Takahashi, Hideaki</creatorcontrib><creatorcontrib>Nakano, Hiroyasu</creatorcontrib><creatorcontrib>Watanabe, Tsunamasa</creatorcontrib><creatorcontrib>Matsunaga, Kotaro</creatorcontrib><creatorcontrib>Matsumoto, Nobuyuki</creatorcontrib><creatorcontrib>Kato, Masaki</creatorcontrib><creatorcontrib>Morita, Ryo</creatorcontrib><creatorcontrib>Michikawa, Yousuke</creatorcontrib><creatorcontrib>Tamura, Tomohiro</creatorcontrib><creatorcontrib>Hiraishi, Tetsuya</creatorcontrib><creatorcontrib>Hattori, Nobuhiro</creatorcontrib><creatorcontrib>Noguchi, Yohei</creatorcontrib><creatorcontrib>Nakahara, Kazunari</creatorcontrib><creatorcontrib>Ikeda, Hiroki</creatorcontrib><creatorcontrib>Ishii, Toshiya</creatorcontrib><creatorcontrib>Okuse, Chiaki</creatorcontrib><creatorcontrib>Sase, Shigeru</creatorcontrib><creatorcontrib>Itoh, Fumio</creatorcontrib><creatorcontrib>Suzuki, Michihiro</creatorcontrib><title>Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The progression of chronic liver disease differs by etiology. The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). 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The aim of this study was to elucidate the difference in disease progression between chronic hepatitis C (CHC) and nonalcoholic fatty liver disease (NAFLD) by means of fibrosis markers, liver function, and hepatic tissue blood flow (TBF). Xenon computed tomography (Xe-CT) was performed in 139 patients with NAFLD and 152 patients with CHC (including liver cirrhosis (LC)). The cutoff values for fibrosis markers were compared between NAFLD and CHC, and correlations between hepatic TBF and liver function tests were examined at each fibrosis stage. The cutoff values for detection of the advanced fibrosis stage were lower in NAFLD than in CHC. Although portal venous TBF (PVTBF) correlated with liver function tests, PVTBF in initial LC caused by nonalcoholic steatohepatitis (NASH-LC) was significantly lower than that in hepatitis C virus (C-LC) (p = 0.014). Conversely, the liver function tests in NASH-LC were higher than those in C-LC (p < 0.05). It is important to recognize the difference between NAFLD and CHC. We concluded that changes in hepatic blood flow occurred during the earliest stage of hepatic fibrosis in patients with NAFLD; therefore, patients with NAFLD need to be followed carefully.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>27649152</pmid><doi>10.3390/ijms17091545</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6738-4382</orcidid><orcidid>https://orcid.org/0000-0002-0915-030X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2016-09, Vol.17 (9), p.1545-1545 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Biomarkers - analysis Disease Progression Female Hemodynamics Hepacivirus - physiology Hepatitis C virus Hepatitis C, Chronic - diagnostic imaging Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - physiopathology Hepatitis C, Chronic - virology Host-Pathogen Interactions Humans Liver - blood supply Liver - diagnostic imaging Liver - physiopathology Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - metabolism Liver Cirrhosis - physiopathology Liver Function Tests - methods Male Middle Aged Non-alcoholic Fatty Liver Disease - diagnostic imaging Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - physiopathology Regional Blood Flow - physiology ROC Curve Tomography, X-Ray Computed - methods Xenon |
| title | Correlations of Hepatic Hemodynamics, Liver Function, and Fibrosis Markers in Nonalcoholic Fatty Liver Disease: Comparison with Chronic Hepatitis Related to Hepatitis C Virus |
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