Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer

The MHC class I chain-related molecules (MICs) have previously been shown to be induced on most epithelial tumor cells. Engagement of MIC by the activating immune receptor NKG2D triggers NK cells and augments antigen-specific CTL anti-tumor immunity. The MIC-NKG2D system was proposed to participate...

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Veröffentlicht in:	The Journal of clinical investigation 2004-08, Vol.114 (4), p.560-568
Hauptverfasser:	Wu, Jennifer D, Higgins, Lily M, Steinle, Alexander, Cosman, David, Haugk, Kathy, Plymate, Stephen R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomedical research Carcinoma - metabolism Carcinoma - pathology CD56 Antigen - metabolism Cell Line, Tumor Cytotoxicity, Immunologic Histocompatibility Antigens Class I - metabolism Histocompatibility Antigens Class I - physiology HLA-A Antigens - metabolism HLA-A Antigens - physiology Humans Immunologic Surveillance Interleukin-15 - pharmacology Interleukin-2 - pharmacology Killer Cells, Natural - metabolism Lymphocyte Activation Male Middle Aged NK Cell Lectin-Like Receptor Subfamily K Prostate-Specific Antigen - blood Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Natural Killer Cell T-Lymphocytes, Cytotoxic - immunology Tumor Escape
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