Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities
The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined....
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| Veröffentlicht in: | International journal of molecular sciences 2016-09, Vol.17 (9), p.1478-1478 |
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| container_title | International journal of molecular sciences |
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| creator | Souza, Lucèia Fàtima Caputo, Lucia Inchausti De Barros, Ingrid Bergman Fratianni, Florinda Nazzaro, Filomena De Feo, Vincenzo |
| description | The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression. |
| doi_str_mv | 10.3390/ijms17091478 |
| format | Article |
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The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression.</description><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms17091478</identifier><identifier>PMID: 27598154</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Aculeata ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Aspergillus versicolor ; Bacillus cereus ; Cactaceae ; Cactaceae - chemistry ; Cell Line, Tumor ; Escherichia coli ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - pharmacology ; Humans ; Neurons - drug effects ; Oils, Volatile - analysis ; Pereskia aculeata ; Phenols - analysis ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Staphylococcus aureus</subject><ispartof>International journal of molecular sciences, 2016-09, Vol.17 (9), p.1478-1478</ispartof><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e6fef4dc492a5e1d2de5d67430f392d2dd3ecf22c780d5a5bb2a0336d5ce9f4e3</citedby><cites>FETCH-LOGICAL-c417t-e6fef4dc492a5e1d2de5d67430f392d2dd3ecf22c780d5a5bb2a0336d5ce9f4e3</cites><orcidid>0000-0002-1070-3207 ; 0000-0002-5759-7499 ; 0000-0003-1352-3102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037756/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037756/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27598154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza, Lucèia Fàtima</creatorcontrib><creatorcontrib>Caputo, Lucia</creatorcontrib><creatorcontrib>Inchausti De Barros, Ingrid Bergman</creatorcontrib><creatorcontrib>Fratianni, Florinda</creatorcontrib><creatorcontrib>Nazzaro, Filomena</creatorcontrib><creatorcontrib>De Feo, Vincenzo</creatorcontrib><title>Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The aims of this work were to study the chemical composition of the essential oil from the leaves of Pereskia aculeata and to evaluate some biological activities of three leaf extracts. The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. Treatments of SH-SY5Y neuroblastoma cells with 100 µg/mL of methanol extract significantly reduced ADCY1 expression.</description><subject>Aculeata</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillus versicolor</subject><subject>Bacillus cereus</subject><subject>Cactaceae</subject><subject>Cactaceae - chemistry</subject><subject>Cell Line, Tumor</subject><subject>Escherichia coli</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Humans</subject><subject>Neurons - drug effects</subject><subject>Oils, Volatile - analysis</subject><subject>Pereskia aculeata</subject><subject>Phenols - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Staphylococcus aureus</subject><issn>1422-0067</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1P3DAQxS0E4qvcOKMcqdQt_oxjDkjbiLZIW7WH9sTBmrUnYHDiJU5W6n9PKBQtN04zo_fTmxk9Qo4Z_SyEoWfhrs1MU8OkrrbIPpOczygt9fZGv0cOcr6jlAuuzC7Z41qZiim5T65_YY_5PkABbowIAxQ_xhixL05rcAM4BPxYLBDWmM-L-hbb4CAWdWpXKYchpK6AzhdfQorp5p80d0NYTwrmD2SngZjx6KUekj9fL3_X32eLn9-u6vli5iTTwwzLBhvpnTQcFDLPPSpfailoIwyfRi_QNZw7XVGvQC2XHKgQpVcOTSNRHJKLZ9_VuGzRO-yGHqJd9aGF_q9NEOxbpQu39iatraJCa1VOBqcvBn16GDEPtg3ZYYzQYRqzZZWi03JD2TtQpispDasm9NMz6vqUc4_N60WM2qfo7GZ0E36y-cUr_D8r8QjoaJak</recordid><startdate>20160903</startdate><enddate>20160903</enddate><creator>Souza, Lucèia Fàtima</creator><creator>Caputo, Lucia</creator><creator>Inchausti De Barros, Ingrid Bergman</creator><creator>Fratianni, Florinda</creator><creator>Nazzaro, Filomena</creator><creator>De Feo, Vincenzo</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1070-3207</orcidid><orcidid>https://orcid.org/0000-0002-5759-7499</orcidid><orcidid>https://orcid.org/0000-0003-1352-3102</orcidid></search><sort><creationdate>20160903</creationdate><title>Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities</title><author>Souza, Lucèia Fàtima ; 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The phenolic content, antioxidant activity, and in vitro antimicrobial and antifungal activities were determined. The methanol extract showed antioxidant activity (EC50 7.09 mg/mL) and high polyphenols content (15.04 ± 0.31 mg gallic acid equivalents (GAE)/g). The petroleum ether extract exhibited potent antibacterial activity against Escherichia coli, whereas the chloroform extract showed inhibitory activity against Bacillus cereus and Staphylococcus aureus. The petroleum ether and methanol extracts were more effective in inhibiting the growth of Aspergillus versicolor. The possible cytotoxicity of extracts on neuroblastoma SH-SY5Y cancer cell line and the influence on adenylate cyclase (ADCY) expression was also studied. P. aculeata chloroform extract showed antiproliferative activity with an IC50 value of 262.83 µg/mL. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aculeata Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - pharmacology Aspergillus versicolor Bacillus cereus Cactaceae Cactaceae - chemistry Cell Line, Tumor Escherichia coli Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Humans Neurons - drug effects Oils, Volatile - analysis Pereskia aculeata Phenols - analysis Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Staphylococcus aureus |
| title | Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities |
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