Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection

Dengue virus (DENV) remains a major public health threat because no vaccine or drugs are available for the prevention and treatment of DENV infection, and the immunopathogenesis mechanisms of DENV infection are not fully understood. Cytotoxic molecules, such as granzyme B (GrzB), may be necessary to...

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Veröffentlicht in:	Cellular & molecular immunology 2016-09, Vol.13 (5), p.700-708
Hauptverfasser:	Liu, Shuyan, Chen, Lingming, Zeng, Ying, Si, Lulu, Guo, Xiaolan, Zhou, Junmei, Fang, Danyun, Zeng, Gucheng, Jiang, Lifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagomirs - pharmacology Antibodies Base Sequence Biomedical and Life Sciences Biomedicine Dengue - genetics Dengue - immunology Dengue - virology Dengue virus Dengue Virus - drug effects Dengue Virus - physiology Down-Regulation - genetics Flaviviridae Granzymes - metabolism Humans Immunology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Medical Microbiology Microbiology MicroRNAs - genetics MicroRNAs - metabolism Perforin - metabolism research-article Vaccine Virus Replication - drug effects
Online-Zugang:	Volltext
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