Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events
The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events. We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for onco...
Gespeichert in:
| Veröffentlicht in: | Circulation. Cardiovascular imaging 2016-04, Vol.9 (4), p.e004043-e004043 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e004043 |
|---|---|
| container_issue | 4 |
| container_start_page | e004043 |
| container_title | Circulation. Cardiovascular imaging |
| container_volume | 9 |
| creator | Figueroa, Amparo L Takx, Richard A P MacNabb, Megan H Abdelbaky, Amr Lavender, Zachary R Kaplan, Rebecca S Truong, Quynh A Lo, Janet Ghoshhajra, Brian B Grinspoon, Steven K Hoffmann, Udo Tawakol, Ahmed |
| description | The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events.
We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined. Additionally, body mass index, metabolic syndrome, and aortic (18)F-fluorodeoxyglucose uptake (a measure of arterial inflammation) were determined. Subsequent development of cardiovascular disease (CVD) events was adjudicated. The analysis included 415 patients with a median age of 55 (P25-P75: 45-65) and a median body mass index of 26.4 (P25-P75: 23.4-30.9) kg/m(2). VAT and SAT volume were significantly higher in obese individuals. VAT volume (r=0.290; P |
| doi_str_mv | 10.1161/CIRCIMAGING.115.004043 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5036397</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1781151908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-cc2f4ac77283bfbee26bda1f6c868536a317b3c204ceac698b01f11aef4bf1113</originalsourceid><addsrcrecordid>eNpVUU1v1DAQtRCIlsJfqHzk0JRxnDjJBWmJyhKpBanA2Zo449YoiRc72ar_HtMtVTnN6M28Nx-PsVMB50Io8aHtrtvuarPtvm4TUJ4DFFDIF-xYNEWeAdTw8iEXWaNKccTexPgLQEko69fsKK-gyiXkx-zmmkZcnJ_jrdvxT7TcEc38ijCugSL3lm8Gt_PRLfdnfBMWCg5H3s12xGl6IJ5xnAf-fe0j_V5pXniLYXB-j9GsIwZ-sU9gfMteWRwjvXuMJ-zn54sf7Zfs8tu2azeXmSlEsWTG5LZAU1V5LXvbE-WqH1BYZWpVl1KhFFUvTQ6FITSqqXsQVggkW_QpCnnCPh50d2s_0WDS7ICj3gU3YbjXHp3-vzK7W33j97oEqWRTJYH3jwLBp3vioicXDY0jzuTXqEVVp3-LBurUqg6tJvgYA9mnMQL0X5f0M5cSUOqDS4l4-nzJJ9o_W-QfTfySQA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781151908</pqid></control><display><type>article</type><title>Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Figueroa, Amparo L ; Takx, Richard A P ; MacNabb, Megan H ; Abdelbaky, Amr ; Lavender, Zachary R ; Kaplan, Rebecca S ; Truong, Quynh A ; Lo, Janet ; Ghoshhajra, Brian B ; Grinspoon, Steven K ; Hoffmann, Udo ; Tawakol, Ahmed</creator><creatorcontrib>Figueroa, Amparo L ; Takx, Richard A P ; MacNabb, Megan H ; Abdelbaky, Amr ; Lavender, Zachary R ; Kaplan, Rebecca S ; Truong, Quynh A ; Lo, Janet ; Ghoshhajra, Brian B ; Grinspoon, Steven K ; Hoffmann, Udo ; Tawakol, Ahmed</creatorcontrib><description>The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events.
We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined. Additionally, body mass index, metabolic syndrome, and aortic (18)F-fluorodeoxyglucose uptake (a measure of arterial inflammation) were determined. Subsequent development of cardiovascular disease (CVD) events was adjudicated. The analysis included 415 patients with a median age of 55 (P25-P75: 45-65) and a median body mass index of 26.4 (P25-P75: 23.4-30.9) kg/m(2). VAT and SAT volume were significantly higher in obese individuals. VAT volume (r=0.290; P<0.001) and VAT/SAT ratio (r=0.208; P<0.001) were positively correlated with arterial inflammation. Thirty-two subjects experienced a CVD event during a median follow-up of 4 years. Cox proportional hazard models showed that VAT volume and VAT/SAT ratio were associated with CVD events (hazard ratio [95% confidence interval]: 1.15 [1.06-1.25]; P<0.001; 3.60 [1.88-6.92]; P<0.001, respectively). Body mass index, metabolic syndrome, and SAT were not predictive of CVD events.
Measures of visceral fat are positively related to arterial inflammation and are independent predictors of subsequent CVD events. Individuals with higher measures of visceral fat as well as elevated arterial inflammation are at highest risk for subsequent CVD events. The findings suggest that arterial inflammation may explain some of the CVD risk associated with adiposity.</description><identifier>ISSN: 1941-9651</identifier><identifier>EISSN: 1942-0080</identifier><identifier>DOI: 10.1161/CIRCIMAGING.115.004043</identifier><identifier>PMID: 27072302</identifier><language>eng</language><publisher>United States</publisher><subject>Adiposity ; Aged ; Arteritis - diagnostic imaging ; Body Mass Index ; Cardiovascular Diseases - diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Metabolic Syndrome - complications ; Middle Aged ; Multimodal Imaging ; Positron-Emission Tomography ; Predictive Value of Tests ; Radiopharmaceuticals ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed</subject><ispartof>Circulation. Cardiovascular imaging, 2016-04, Vol.9 (4), p.e004043-e004043</ispartof><rights>2016 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-cc2f4ac77283bfbee26bda1f6c868536a317b3c204ceac698b01f11aef4bf1113</citedby><cites>FETCH-LOGICAL-c414t-cc2f4ac77283bfbee26bda1f6c868536a317b3c204ceac698b01f11aef4bf1113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27072302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Figueroa, Amparo L</creatorcontrib><creatorcontrib>Takx, Richard A P</creatorcontrib><creatorcontrib>MacNabb, Megan H</creatorcontrib><creatorcontrib>Abdelbaky, Amr</creatorcontrib><creatorcontrib>Lavender, Zachary R</creatorcontrib><creatorcontrib>Kaplan, Rebecca S</creatorcontrib><creatorcontrib>Truong, Quynh A</creatorcontrib><creatorcontrib>Lo, Janet</creatorcontrib><creatorcontrib>Ghoshhajra, Brian B</creatorcontrib><creatorcontrib>Grinspoon, Steven K</creatorcontrib><creatorcontrib>Hoffmann, Udo</creatorcontrib><creatorcontrib>Tawakol, Ahmed</creatorcontrib><title>Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events</title><title>Circulation. Cardiovascular imaging</title><addtitle>Circ Cardiovasc Imaging</addtitle><description>The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events.
We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined. Additionally, body mass index, metabolic syndrome, and aortic (18)F-fluorodeoxyglucose uptake (a measure of arterial inflammation) were determined. Subsequent development of cardiovascular disease (CVD) events was adjudicated. The analysis included 415 patients with a median age of 55 (P25-P75: 45-65) and a median body mass index of 26.4 (P25-P75: 23.4-30.9) kg/m(2). VAT and SAT volume were significantly higher in obese individuals. VAT volume (r=0.290; P<0.001) and VAT/SAT ratio (r=0.208; P<0.001) were positively correlated with arterial inflammation. Thirty-two subjects experienced a CVD event during a median follow-up of 4 years. Cox proportional hazard models showed that VAT volume and VAT/SAT ratio were associated with CVD events (hazard ratio [95% confidence interval]: 1.15 [1.06-1.25]; P<0.001; 3.60 [1.88-6.92]; P<0.001, respectively). Body mass index, metabolic syndrome, and SAT were not predictive of CVD events.
Measures of visceral fat are positively related to arterial inflammation and are independent predictors of subsequent CVD events. Individuals with higher measures of visceral fat as well as elevated arterial inflammation are at highest risk for subsequent CVD events. The findings suggest that arterial inflammation may explain some of the CVD risk associated with adiposity.</description><subject>Adiposity</subject><subject>Aged</subject><subject>Arteritis - diagnostic imaging</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - diagnostic imaging</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Syndrome - complications</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>1941-9651</issn><issn>1942-0080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1v1DAQtRCIlsJfqHzk0JRxnDjJBWmJyhKpBanA2Zo449YoiRc72ar_HtMtVTnN6M28Nx-PsVMB50Io8aHtrtvuarPtvm4TUJ4DFFDIF-xYNEWeAdTw8iEXWaNKccTexPgLQEko69fsKK-gyiXkx-zmmkZcnJ_jrdvxT7TcEc38ijCugSL3lm8Gt_PRLfdnfBMWCg5H3s12xGl6IJ5xnAf-fe0j_V5pXniLYXB-j9GsIwZ-sU9gfMteWRwjvXuMJ-zn54sf7Zfs8tu2azeXmSlEsWTG5LZAU1V5LXvbE-WqH1BYZWpVl1KhFFUvTQ6FITSqqXsQVggkW_QpCnnCPh50d2s_0WDS7ICj3gU3YbjXHp3-vzK7W33j97oEqWRTJYH3jwLBp3vioicXDY0jzuTXqEVVp3-LBurUqg6tJvgYA9mnMQL0X5f0M5cSUOqDS4l4-nzJJ9o_W-QfTfySQA</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Figueroa, Amparo L</creator><creator>Takx, Richard A P</creator><creator>MacNabb, Megan H</creator><creator>Abdelbaky, Amr</creator><creator>Lavender, Zachary R</creator><creator>Kaplan, Rebecca S</creator><creator>Truong, Quynh A</creator><creator>Lo, Janet</creator><creator>Ghoshhajra, Brian B</creator><creator>Grinspoon, Steven K</creator><creator>Hoffmann, Udo</creator><creator>Tawakol, Ahmed</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events</title><author>Figueroa, Amparo L ; Takx, Richard A P ; MacNabb, Megan H ; Abdelbaky, Amr ; Lavender, Zachary R ; Kaplan, Rebecca S ; Truong, Quynh A ; Lo, Janet ; Ghoshhajra, Brian B ; Grinspoon, Steven K ; Hoffmann, Udo ; Tawakol, Ahmed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-cc2f4ac77283bfbee26bda1f6c868536a317b3c204ceac698b01f11aef4bf1113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adiposity</topic><topic>Aged</topic><topic>Arteritis - diagnostic imaging</topic><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - diagnostic imaging</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Syndrome - complications</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Figueroa, Amparo L</creatorcontrib><creatorcontrib>Takx, Richard A P</creatorcontrib><creatorcontrib>MacNabb, Megan H</creatorcontrib><creatorcontrib>Abdelbaky, Amr</creatorcontrib><creatorcontrib>Lavender, Zachary R</creatorcontrib><creatorcontrib>Kaplan, Rebecca S</creatorcontrib><creatorcontrib>Truong, Quynh A</creatorcontrib><creatorcontrib>Lo, Janet</creatorcontrib><creatorcontrib>Ghoshhajra, Brian B</creatorcontrib><creatorcontrib>Grinspoon, Steven K</creatorcontrib><creatorcontrib>Hoffmann, Udo</creatorcontrib><creatorcontrib>Tawakol, Ahmed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Circulation. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Figueroa, Amparo L</au><au>Takx, Richard A P</au><au>MacNabb, Megan H</au><au>Abdelbaky, Amr</au><au>Lavender, Zachary R</au><au>Kaplan, Rebecca S</au><au>Truong, Quynh A</au><au>Lo, Janet</au><au>Ghoshhajra, Brian B</au><au>Grinspoon, Steven K</au><au>Hoffmann, Udo</au><au>Tawakol, Ahmed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events</atitle><jtitle>Circulation. Cardiovascular imaging</jtitle><addtitle>Circ Cardiovasc Imaging</addtitle><date>2016-04</date><risdate>2016</risdate><volume>9</volume><issue>4</issue><spage>e004043</spage><epage>e004043</epage><pages>e004043-e004043</pages><issn>1941-9651</issn><eissn>1942-0080</eissn><abstract>The objective of this study was to evaluate how different measures of adiposity are related to both arterial inflammation and the risk of subsequent cardiovascular events.
We included individuals who underwent (18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging for oncological evaluation. Subcutaneous adipose tissue (SAT) volume, visceral adipose tissue (VAT) volume, and VAT/SAT ratio were determined. Additionally, body mass index, metabolic syndrome, and aortic (18)F-fluorodeoxyglucose uptake (a measure of arterial inflammation) were determined. Subsequent development of cardiovascular disease (CVD) events was adjudicated. The analysis included 415 patients with a median age of 55 (P25-P75: 45-65) and a median body mass index of 26.4 (P25-P75: 23.4-30.9) kg/m(2). VAT and SAT volume were significantly higher in obese individuals. VAT volume (r=0.290; P<0.001) and VAT/SAT ratio (r=0.208; P<0.001) were positively correlated with arterial inflammation. Thirty-two subjects experienced a CVD event during a median follow-up of 4 years. Cox proportional hazard models showed that VAT volume and VAT/SAT ratio were associated with CVD events (hazard ratio [95% confidence interval]: 1.15 [1.06-1.25]; P<0.001; 3.60 [1.88-6.92]; P<0.001, respectively). Body mass index, metabolic syndrome, and SAT were not predictive of CVD events.
Measures of visceral fat are positively related to arterial inflammation and are independent predictors of subsequent CVD events. Individuals with higher measures of visceral fat as well as elevated arterial inflammation are at highest risk for subsequent CVD events. The findings suggest that arterial inflammation may explain some of the CVD risk associated with adiposity.</abstract><cop>United States</cop><pmid>27072302</pmid><doi>10.1161/CIRCIMAGING.115.004043</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1941-9651 |
| ispartof | Circulation. Cardiovascular imaging, 2016-04, Vol.9 (4), p.e004043-e004043 |
| issn | 1941-9651 1942-0080 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5036397 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adiposity Aged Arteritis - diagnostic imaging Body Mass Index Cardiovascular Diseases - diagnostic imaging Female Fluorodeoxyglucose F18 Humans Male Metabolic Syndrome - complications Middle Aged Multimodal Imaging Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Retrospective Studies Risk Factors Tomography, X-Ray Computed |
| title | Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A18%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20Between%20Measures%20of%20Adiposity,%20Arterial%20Inflammation,%20and%20Subsequent%20Cardiovascular%20Events&rft.jtitle=Circulation.%20Cardiovascular%20imaging&rft.au=Figueroa,%20Amparo%20L&rft.date=2016-04&rft.volume=9&rft.issue=4&rft.spage=e004043&rft.epage=e004043&rft.pages=e004043-e004043&rft.issn=1941-9651&rft.eissn=1942-0080&rft_id=info:doi/10.1161/CIRCIMAGING.115.004043&rft_dat=%3Cproquest_pubme%3E1781151908%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781151908&rft_id=info:pmid/27072302&rfr_iscdi=true |