Aging of hematopoietic stem cells: DNA damage and mutations?

Aging in the hematopoietic system and the stem cell niche contributes to aging-associated phenotypes of hematopoietic stem cells (HSCs), including leukemia and aging-associated immune remodeling. Among others, the DNA damage theory of aging of HSCs is well established, based on the detection of a si...

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Veröffentlicht in:	Experimental hematology 2016-10, Vol.44 (10), p.895-901
Hauptverfasser:	Moehrle, Bettina M, Geiger, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Aging Animals Apoptosis Cell Cycle Cell Differentiation Cellular Senescence - genetics DNA Damage Epigenesis, Genetic Hematology, Oncology and Palliative Medicine Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Mutation Oxidative Stress
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