Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

Excitatory neurotransmission plays a key role in epileptogenesis. Correspondingly, AMPA-subtype ionotropic glutamate receptors, which mediate the majority of excitatory neurotransmission and contribute to seizure generation and spread, have emerged as promising targets for epilepsy therapy. The most...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2016-09, Vol.91 (6), p.1305-1315
Hauptverfasser:	Yelshanskaya, Maria V., Singh, Appu K., Sampson, Jared M., Narangoda, Chamali, Kurnikova, Maria, Sobolevsky, Alexander I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - chemistry Anticonvulsants - pharmacology Benzodiazepines - chemistry Benzodiazepines - pharmacology Binding Sites - drug effects Crystallization Data collection Drug dosages Ligands Molecular Docking Simulation Mutagenesis Proteins Pyridones - chemistry Pyridones - pharmacology Quinazolines - chemistry Quinazolines - pharmacology Rats Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - chemistry Receptors, AMPA - metabolism
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