Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

Liver kinase B1 (LKB1) and its downstream effector AMP‐activated protein kinase (AMPK) play critical roles in polarity establishment by regulating membrane trafficking and energy metabolism. In collagen sandwich‐cultured hepatocytes, loss of LKB1 or AMPK impaired apical ABCB11 (Bsep) trafficking and...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2016-10, Vol.64 (4), p.1317-1329
Hauptverfasser:	Porat‐Shliom, Natalie, Tietgens, Amber J., Itallie, Christina M., Vitale‐Cross, Lynn, Jarnik, Michal, Harding, Olivia J., Anderson, James M., Gutkind, J. Silvio, Weigert, Roberto, Arias, Irwin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Hepatocytes - physiology Hepatocytes - ultrastructure Hepatology Kinases Liver Biology/Pathobiology Male Mice Mice, Knockout Microscopy Protein-Serine-Threonine Kinases - physiology Rodents Tight Junctions - physiology Tight Junctions - ultrastructure
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