Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly
Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in p...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2016-08, Vol.8 (8), p.1690-1702 |
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| creator | Brzeszczyńska, Joanna Johns, Neil Schilb, Alain Degen, Simone Degen, Martin Langen, Ramon Schols, Annemie Glass, David J Roubenoff, Ronenn Greig, Carolyn A Jacobi, Carsten Fearon, Kenneth Ch Ross, James A |
| description | Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p≤0.001). In contrast, the expression of the late myogenic differentiation marker MyoG was reduced in CWS and CWL but increased in HE (p≤0.0001). Bax was significantly increased in CWS, CWL and HE (p≤0.0001). Expression of the oxidative defense genes SOD2, GCLM, and Nrf2 was decreased in CWS and CWL but increased in HE (p≤0.0001). There is evidence for blockade of satellite cell maturation, upregulation of apoptosis and reduced oxidative defense in the muscle of cancer patients. In the healthy elderly the potential for differentiation and oxidative defense is maintained. |
| doi_str_mv | 10.18632/aging.101006 |
| format | Article |
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This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p≤0.001). In contrast, the expression of the late myogenic differentiation marker MyoG was reduced in CWS and CWL but increased in HE (p≤0.0001). Bax was significantly increased in CWS, CWL and HE (p≤0.0001). Expression of the oxidative defense genes SOD2, GCLM, and Nrf2 was decreased in CWS and CWL but increased in HE (p≤0.0001). There is evidence for blockade of satellite cell maturation, upregulation of apoptosis and reduced oxidative defense in the muscle of cancer patients. In the healthy elderly the potential for differentiation and oxidative defense is maintained.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.101006</identifier><identifier>PMID: 27454226</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Aged ; Aged, 80 and over ; Cachexia - metabolism ; Cachexia - pathology ; Female ; Humans ; Male ; Middle Aged ; Muscle Development - physiology ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscular Atrophy - metabolism ; Muscular Atrophy - pathology ; Neoplasms - metabolism ; Neoplasms - pathology ; Research Paper ; Satellite Cells, Skeletal Muscle - metabolism ; Satellite Cells, Skeletal Muscle - pathology</subject><ispartof>Aging (Albany, NY.), 2016-08, Vol.8 (8), p.1690-1702</ispartof><rights>Copyright: © 2016 Brzeszczyńska et al. 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-a156ade28d489c61e5c31a314af863264d49b4a8445edc443868a87d42e5c0cd3</citedby><cites>FETCH-LOGICAL-c387t-a156ade28d489c61e5c31a314af863264d49b4a8445edc443868a87d42e5c0cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032690/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032690/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27454226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brzeszczyńska, Joanna</creatorcontrib><creatorcontrib>Johns, Neil</creatorcontrib><creatorcontrib>Schilb, Alain</creatorcontrib><creatorcontrib>Degen, Simone</creatorcontrib><creatorcontrib>Degen, Martin</creatorcontrib><creatorcontrib>Langen, Ramon</creatorcontrib><creatorcontrib>Schols, Annemie</creatorcontrib><creatorcontrib>Glass, David J</creatorcontrib><creatorcontrib>Roubenoff, Ronenn</creatorcontrib><creatorcontrib>Greig, Carolyn A</creatorcontrib><creatorcontrib>Jacobi, Carsten</creatorcontrib><creatorcontrib>Fearon, Kenneth Ch</creatorcontrib><creatorcontrib>Ross, James A</creatorcontrib><title>Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p≤0.001). In contrast, the expression of the late myogenic differentiation marker MyoG was reduced in CWS and CWL but increased in HE (p≤0.0001). Bax was significantly increased in CWS, CWL and HE (p≤0.0001). Expression of the oxidative defense genes SOD2, GCLM, and Nrf2 was decreased in CWS and CWL but increased in HE (p≤0.0001). There is evidence for blockade of satellite cell maturation, upregulation of apoptosis and reduced oxidative defense in the muscle of cancer patients. In the healthy elderly the potential for differentiation and oxidative defense is maintained.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cachexia - metabolism</subject><subject>Cachexia - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Development - physiology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Atrophy - metabolism</subject><subject>Muscular Atrophy - pathology</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Research Paper</subject><subject>Satellite Cells, Skeletal Muscle - metabolism</subject><subject>Satellite Cells, Skeletal Muscle - pathology</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv1DAQhSMEoqVw5Ip85JJix3bWuSChClqklbjA2Zq1JxtTx15sp7C_hT-Ld7etymlG8veen-Y1zVtGL5nqefcBti5sLxlllPbPmnM2CNkKqYbnT_az5lXOPysgpehfNmfdSkjRdf1583cdcyZxJPGPs1DcHRKLI4aMBIIlu1gwFAeebHw0t2DxwGYo6L0rSEydZIaypKqNgbhAyoQk36LHUlXzko0_anYVqFaZ_HZlIgaCwUQ2SyEhlgfZhODLtCfoLSa_f928GMFnfHM_L5ofXz5_v7pp19-uv159WreGq1Vpgcm-BuuUFWowPUNpOAPOBIyHA_XCimEjQAkh0RohuOoVqJUVXSWpsfyi-Xjy3S2buSI1ZgKvd8nNkPY6gtP_vwQ36W2805JW-4FWg_f3Bin-WjAXPbt8OA0EjEvWTDHFOVvRoaLtCTWpHj7h-PgNo_pYqD4Wqk-FVv7d02yP9EOD_B9ERqEg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Brzeszczyńska, Joanna</creator><creator>Johns, Neil</creator><creator>Schilb, Alain</creator><creator>Degen, Simone</creator><creator>Degen, Martin</creator><creator>Langen, Ramon</creator><creator>Schols, Annemie</creator><creator>Glass, David J</creator><creator>Roubenoff, Ronenn</creator><creator>Greig, Carolyn A</creator><creator>Jacobi, Carsten</creator><creator>Fearon, Kenneth Ch</creator><creator>Ross, James A</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly</title><author>Brzeszczyńska, Joanna ; Johns, Neil ; Schilb, Alain ; Degen, Simone ; Degen, Martin ; Langen, Ramon ; Schols, Annemie ; Glass, David J ; Roubenoff, Ronenn ; Greig, Carolyn A ; Jacobi, Carsten ; Fearon, Kenneth Ch ; Ross, James A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-a156ade28d489c61e5c31a314af863264d49b4a8445edc443868a87d42e5c0cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cachexia - metabolism</topic><topic>Cachexia - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Development - physiology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Atrophy - metabolism</topic><topic>Muscular Atrophy - pathology</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Research Paper</topic><topic>Satellite Cells, Skeletal Muscle - metabolism</topic><topic>Satellite Cells, Skeletal Muscle - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Brzeszczyńska, Joanna</creatorcontrib><creatorcontrib>Johns, Neil</creatorcontrib><creatorcontrib>Schilb, Alain</creatorcontrib><creatorcontrib>Degen, Simone</creatorcontrib><creatorcontrib>Degen, Martin</creatorcontrib><creatorcontrib>Langen, Ramon</creatorcontrib><creatorcontrib>Schols, Annemie</creatorcontrib><creatorcontrib>Glass, David J</creatorcontrib><creatorcontrib>Roubenoff, Ronenn</creatorcontrib><creatorcontrib>Greig, Carolyn A</creatorcontrib><creatorcontrib>Jacobi, Carsten</creatorcontrib><creatorcontrib>Fearon, Kenneth Ch</creatorcontrib><creatorcontrib>Ross, James A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brzeszczyńska, Joanna</au><au>Johns, Neil</au><au>Schilb, Alain</au><au>Degen, Simone</au><au>Degen, Martin</au><au>Langen, Ramon</au><au>Schols, Annemie</au><au>Glass, David J</au><au>Roubenoff, Ronenn</au><au>Greig, Carolyn A</au><au>Jacobi, Carsten</au><au>Fearon, Kenneth Ch</au><au>Ross, James A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>8</volume><issue>8</issue><spage>1690</spage><epage>1702</epage><pages>1690-1702</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>Muscle wasting in old age or cancer may result from failed myofiber regeneration and/or accelerated atrophy. This study aimed to determine from transcriptomic analysis of human muscle the integrity of the cellular stress response system in relation to satellite cell differentiation or apoptosis in patients with cancer (weight-stable (CWS) or weight-losing (CWL)) or healthy elderly (HE) when compared with healthy middle-aged controls (HMA). 28 patients with cancer (CWS: 18 and CWL: 10), HE: 21 and HMA: 20 underwent biopsy of quadriceps muscle. The expression of transcription factors for muscle regeneration (Pax3, Pax7 and MyoD) was increased in CWS and HE compared with HMA (p≤0.001). In contrast, the expression of the late myogenic differentiation marker MyoG was reduced in CWS and CWL but increased in HE (p≤0.0001). Bax was significantly increased in CWS, CWL and HE (p≤0.0001). Expression of the oxidative defense genes SOD2, GCLM, and Nrf2 was decreased in CWS and CWL but increased in HE (p≤0.0001). There is evidence for blockade of satellite cell maturation, upregulation of apoptosis and reduced oxidative defense in the muscle of cancer patients. In the healthy elderly the potential for differentiation and oxidative defense is maintained.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>27454226</pmid><doi>10.18632/aging.101006</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1945-4589 |
| ispartof | Aging (Albany, NY.), 2016-08, Vol.8 (8), p.1690-1702 |
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| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Aged Aged, 80 and over Cachexia - metabolism Cachexia - pathology Female Humans Male Middle Aged Muscle Development - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - metabolism Muscular Atrophy - pathology Neoplasms - metabolism Neoplasms - pathology Research Paper Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology |
| title | Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly |
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