Umbilical Cord‐Derived Mesenchymal Stem Cell‐Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor‐β/SMAD2 Pathway During Wound Healing

Excessive scar formation caused by myofibroblast aggregations is of great clinical importance during skin wound healing. Umbilical cord‐derived mesenchymal stem cells (uMSCs) reduced scar formation and myofibroblast accumulation in a skin‐defect mouse model. A novel role of exosomal microRNAs in uMS...

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Veröffentlicht in:	Stem cells translational medicine 2016-10, Vol.5 (10), p.1425-1439
Hauptverfasser:	Fang, Shuo, Xu, Chen, Zhang, Yuntong, Xue, Chunyu, Yang, Chao, Bi, Hongda, Qian, Xijing, Wu, Minjuan, Ji, Kaihong, Zhao, Yunpeng, Wang, Yue, Liu, Houqi, Xing, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administrative support Animals Cell Differentiation Cell Separation Cicatrix - metabolism Cicatrix - pathology Data analysis Data collection Disease Models, Animal Exosome Exosomes Exosomes - metabolism Fibroblasts Flow Cytometry Fluorescent Antibody Technique Growth factors High-Throughput Nucleotide Sequencing Humans Hydrogels In Situ Hybridization, Fluorescence Kinases Laboratory animals Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Mice Mice, Inbred BALB C Mice, Inbred ICR MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Myofibroblast Myofibroblasts - cytology Scars Signal Transduction - physiology Skin Smad2 protein Smad2 Protein - metabolism Stem cell transplantation Stem cells Tissue Engineering and Regenerative Medicine Transforming Growth Factor beta - metabolism Transforming growth factor-b Transforming growth factor-β Umbilical cord Umbilical Cord - cytology Wound healing Writing
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