Fibrils of Truncated Pyroglutamyl-Modified Aβ Peptide Exhibit a Similar Structure as Wildtype Mature Aβ Fibrils

Fibrillation of differently modified amyloid β peptides and deposition as senile plaques are hallmarks of Alzheimer’s disease. N-terminally truncated variants, where the glutamate residue 3 is converted into cyclic pyroglutamate (pGlu), form particularly toxic aggregates. We compare the molecular st...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.33531, Article 33531
Hauptverfasser:	Scheidt, Holger A., Adler, Juliane, Krueger, Martin, Huster, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/470/2284 631/535/878/1264 631/57/2272/2273 Amyloid - chemistry Amyloid - ultrastructure Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - ultrastructure Carbon-13 Magnetic Resonance Spectroscopy Fluorescence Humanities and Social Sciences multidisciplinary Pyrrolidonecarboxylic Acid - chemistry Science Thiazoles - chemistry
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