Procedures for risk-stratification of lung cancer using buccal nanocytology
Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique in...
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| Veröffentlicht in: | Biomedical optics express 2016-09, Vol.7 (9), p.3795-3810 |
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| creator | Subramanian, H Viswanathan, P Cherkezyan, L Iyengar, R Rozhok, S Verleye, M Derbas, J Czarnecki, J Roy, H K Backman, V |
| description | Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians' office. |
| doi_str_mv | 10.1364/BOE.7.003795 |
| format | Article |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| title | Procedures for risk-stratification of lung cancer using buccal nanocytology |
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