Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway

Vascular endothelial cells (ECs) appear to be one of the primary targets of hypoxia/reoxygenation (H/R) injury. In our previous study, we demonstrated that hepatocyte growth factor (HGF) exhibited a protective effect in cardiac microvascular endothelial cells (CMECs) subjected to H/R by inhibiting x...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular medicine 2016-10, Vol.38 (4), p.1055-1062
Hauptverfasser:	Zhang, Ying Qian, Hu, Shun Ying, Chen, Yun Dai, Guo, Ming Zhou, Wang, Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium channels Cardiovascular disease Cell Hypoxia - drug effects Cellular signal transduction Cytosol - metabolism Down-Regulation - drug effects endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - enzymology Enzyme Activation - drug effects Enzymes Gene Knockdown Techniques Genetic aspects Growth factors Health aspects hepatocyte growth factor Hepatocyte Growth Factor - pharmacology Hypoxia hypoxia/reoxygenation janus kinase 2 Janus Kinase 2 - metabolism Kinases Laboratory animals Oxidases Oxygen - pharmacology Phosphatidylinositol 3-Kinases - metabolism Properties Proteins Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Small Interfering - metabolism Rodents Signal Transduction - drug effects Substance abuse treatment xanthine oxidase Xanthine Oxidase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!