The molecular mechanisms of action of PPAR-γ agonists in the treatment of corneal alkali burns (Review)

Corneal alkali burns (CAB) are characterized by injury-induced inflammation, fibrosis and neovascularization (NV), and may lead to blindness. This review evaluates the current knowledge of the molecular mechanisms responsible for CAB. The processes of cytokine production, chemotaxis, inflammatory re...

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Veröffentlicht in:	International journal of molecular medicine 2016-10, Vol.38 (4), p.1003-1011
Hauptverfasser:	Zhou, Hongyan, Zhang, Wensong, Bi, Miaomiao, Wu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Alkalies Angiogenesis Atherosclerosis Burns Burns, Chemical Care and treatment Cell adhesion & migration Chemokines Complications and side effects Cornea Cornea - pathology corneal alkali burn corneal neovascularization Cytokines Eye Burns - drug therapy Eye Burns - metabolism Gene expression Genetic aspects Humans Immune response Inflammation Injuries Kinases Ligands Observations peroxisome proliferator-activated receptor-γ PPAR gamma - agonists PPAR gamma - metabolism Proteins Risk factors Scars Signal transduction Stem cells Studies Translational Medical Research Tumor necrosis factor-TNF Vascular endothelial growth factor Wound Healing
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