Folding recombinant spider‐silk in H2O: Effect of osmolytes on the solution conformation of a 15‐repeat spider‐silk mimetic

The folding of a recombinant spider silk protein‐polymer in the presence of the tri‐methylamine osmolytes TMANO and Betaine in 80% H2O is reported. Circular dichroism measurements (CD) reveal an increase in α‐helical secondary structure with increasing osmolyte concentrations, as determined by an in...

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Veröffentlicht in:	Protein science 2016-10, Vol.25 (10), p.1853-1862
Hauptverfasser:	McLachlan, Glendon D., Gandjian, Babak, Alhumaidan, Hind
Format:	Artikel
Sprache:	eng
Schlagworte:	betaine circular dichroism osmolytes protein folding sarcosine Silk Spiders spider‐silk mimetic taurine TMANO
Online-Zugang:	Volltext
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