Hodgkin's disease in a patient with common variable immunodeficiency

A 61 year old man with long standing common variable immunodeficiency presented with pyrexia, anaemia and leucopenia. A diagnoses of Hodgkin's disease of the bone marrow was made. The typical histopathological and immunophenotypic appearances were clearly distinct from those of T cell lymphoma...

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Veröffentlicht in:Journal of clinical pathology 1995-09, Vol.48 (9), p.871-873
Hauptverfasser: Christopoulos, C, Papadaki, T, Vlavianos, P, Kokkini, G
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container_title Journal of clinical pathology
container_volume 48
creator Christopoulos, C
Papadaki, T
Vlavianos, P
Kokkini, G
description A 61 year old man with long standing common variable immunodeficiency presented with pyrexia, anaemia and leucopenia. A diagnoses of Hodgkin's disease of the bone marrow was made. The typical histopathological and immunophenotypic appearances were clearly distinct from those of T cell lymphoma with Reed-Sternberg-like cells which, in contrast to Hodgkin's disease, is a known complication of common variable immunodeficiency. Complete clinical and histological remission was achieved with combination chemotherapy. The latter was complicated by severe myelosuppression, unusually severe erosive mucositis and viral retinitis.
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A diagnoses of Hodgkin's disease of the bone marrow was made. The typical histopathological and immunophenotypic appearances were clearly distinct from those of T cell lymphoma with Reed-Sternberg-like cells which, in contrast to Hodgkin's disease, is a known complication of common variable immunodeficiency. Complete clinical and histological remission was achieved with combination chemotherapy. 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A diagnoses of Hodgkin's disease of the bone marrow was made. The typical histopathological and immunophenotypic appearances were clearly distinct from those of T cell lymphoma with Reed-Sternberg-like cells which, in contrast to Hodgkin's disease, is a known complication of common variable immunodeficiency. Complete clinical and histological remission was achieved with combination chemotherapy. The latter was complicated by severe myelosuppression, unusually severe erosive mucositis and viral retinitis.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Common Variable Immunodeficiency - complications</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Hodgkin Disease - etiology</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. 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subjects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Common Variable Immunodeficiency - complications
Hematologic and hematopoietic diseases
Hodgkin Disease - drug therapy
Hodgkin Disease - etiology
Hodgkin Disease - pathology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
title Hodgkin's disease in a patient with common variable immunodeficiency
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