Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases

•DME and ROS1 DNA glycosylases excise both 5mC and 5hmC from DNA.•DNA demethylation can be reconstituted via 5hmC excision and subsequent BER.•Plants have no detectable amount of 5hmC in the genome.•Plants and animals have evolved distinct DNA demethylation systems. In plants and animals, 5-methylcy...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-04, Vol.446 (4), p.1067-1072
Hauptverfasser:	Jang, Hosung, Shin, Hosub, Eichman, Brandt F., Huh, Jin Hoe
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxymethylcytosine 5-Methylcytosine 5-Methylcytosine - metabolism Animals Arabidopsis - metabolism Arabidopsis Proteins - metabolism Cytosine - analogs & derivatives Cytosine - metabolism DEMETER DNA demethylation DNA glycosylase DNA Glycosylases - metabolism DNA Methylation Mice N-Glycosyl Hydrolases - metabolism Nuclear Proteins - metabolism Signal Transduction Trans-Activators - metabolism
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