A novel intrinsic analgesic mechanism: the enhancement of the conduction failure along polymodal nociceptive C-fibers

Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances...

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Veröffentlicht in:	Pain (Amsterdam) 2016-10, Vol.157 (10), p.2235-2247
Hauptverfasser:	Wang, Xiuchao, Wang, Shan, Wang, Wenting, Duan, Jianhong, Zhang, Ming, Lv, Xiaohua, Niu, Chunxiao, Tan, Chao, Wu, Yuanbin, Yang, Jing, Hu, Sanjue, Xing, Junling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biophysics Calcium - metabolism Disease Models, Animal Female Freund's Adjuvant - toxicity Ganglia, Spinal - cytology Hyperalgesia - physiopathology Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Inflammation - chemically induced Inflammation - complications Membrane Potentials - drug effects Membrane Potentials - physiology Nerve Fibers, Unmyelinated - drug effects Nerve Fibers, Unmyelinated - physiology Neural Conduction - drug effects Neural Conduction - physiology Neurons - drug effects Neurons - physiology Pain - etiology Pain - pathology Pain Threshold - drug effects Patch-Clamp Techniques Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Research Paper
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