TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood

After invading red blood cells (RBCs), Plasmodium falciparum ( Pf ) can export its own proteins to the host membrane and activate endogenous channels that are present in the membrane of RBCs. This transport pathway involves the Voltage Dependent Anion Channel (VDAC). Moreover, ligands of the VDAC pa...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.33516-33516, Article 33516
Hauptverfasser:	Marginedas-Freixa, I., Hattab, C., Bouyer, G., Halle, F., Chene, A., Lefevre, S. D., Cambot, M., Cueff, A., Schmitt, M., Gamain, B., Lacapere, J. J., Egee, S., Bihel, F., Le Van Kim, C., Ostuni, M. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/34 38/1 38/77 631/45 631/80 82/1 82/29 82/58 Accumulation Amino Acid Sequence Animals Antigens, CD34 - metabolism Biological Transport Cell Differentiation Cellular Biology Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - metabolism Erythrocytes - parasitology Erythroid cells Erythroid Cells - cytology Erythroid Cells - metabolism Gene Expression Profiling Glutathione - metabolism Hematology Human health and pathology Humanities and Social Sciences Humans Infectious diseases Isoforms Life Sciences Ligands Mass Spectrometry Membranes Microbiology and Parasitology multidisciplinary Parasites Parasites - growth & development Parasitology Plasmodium falciparum Plasmodium falciparum - growth & development Porphyrins Protein Isoforms - genetics Protein Isoforms - metabolism Protoporphyrin Protoporphyrins - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, GABA - chemistry Receptors, GABA - genetics Receptors, GABA - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Subcellular Processes Voltage-Dependent Anion Channels - chemistry Voltage-Dependent Anion Channels - metabolism
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