Mechanism of endonuclease cleavage by the HigB toxin

Bacteria encode multiple type II toxin-antitoxin modules that cleave ribosome-bound mRNAs in response to stress. All ribosome-dependent toxin family members structurally characterized to date adopt similar microbial RNase architectures despite possessing low sequence identities. Therefore, determini...

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Veröffentlicht in:	Nucleic acids research 2016-09, Vol.44 (16), p.7944-7953
Hauptverfasser:	Schureck, Marc A, Repack, Adrienne, Miles, Stacey J, Marquez, Jhomar, Dunham, Christine M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Toxins - chemistry Bacterial Toxins - metabolism BASIC BIOLOGICAL SCIENCES Crystallography, X-Ray Endoribonucleases - metabolism Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism Structural Biology
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