The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

Detergent insoluble inclusions of TDP-43 protein are hallmarks of the neuropathology in over 90 % of amyotrophic lateral sclerosis (ALS) cases and approximately half of frontotemporal dementia (FTLD-TDP) cases. In TDP-43 proteinopathy disorders, lesions containing aggregated TDP-43 protein are exten...

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Veröffentlicht in:	Acta neuropathologica 2016-10, Vol.132 (4), p.545-561
Hauptverfasser:	Liachko, Nicole F., Saxton, Aleen D., McMillan, Pamela J., Strovas, Timothy J., Currey, Heather N., Taylor, Laura M., Wheeler, Jeanna M., Oblak, Adrian L., Ghetti, Bernardino, Montine, Thomas J., Keene, C. Dirk, Raskind, Murray A., Bird, Thomas D., Kraemer, Brian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acids Amyotrophic lateral sclerosis Animals Brain - metabolism Brain - pathology Caenorhabditis elegans Calcineurin - metabolism Cells (Biology) Dementia Disease DNA-Binding Proteins - metabolism Inclusion Bodies - pathology Kinases Medicine Medicine & Public Health Nervous system diseases Neurodegeneration Neurons - metabolism Neurons - pathology Neuropathology Neurosciences Original Paper Pathology Phosphatase Phosphatases Phosphoric Monoester Hydrolases - metabolism Phosphorylation Phosphotransferases Plasmids Proteins TDP-43 Proteinopathies - metabolism TDP-43 Proteinopathies - pathology
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