Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipo...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2016-10, Vol.41 (11), p.2679-2687
Hauptverfasser:	Trost, Sarah, Diekhof, Esther K, Mohr, Holger, Vieker, Henning, Krämer, Bernd, Wolf, Claudia, Keil, Maria, Dechent, Peter, Binder, Elisabeth B, Gruber, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aging Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - genetics Brain - diagnostic imaging Brain Mapping Brain research Cell Cycle Proteins - genetics Conditioning, Operant Consortia Female Gene expression Genetic engineering Genome-Wide Association Study Genomes Genotype Health risk assessment Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical imaging Mutation Neural Pathways - diagnostic imaging Neuroimaging Neurosciences Nuclear Proteins - genetics Original Oxygen - blood Personality Inventory Polymorphism Polymorphism, Single Nucleotide - genetics Psychiatry Psychotherapy Reward Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - genetics Young Adult
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