Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor

Prostate inflammation has been suggested as an etiology for benign prostatic hyperplasia (BPH). We show that decreased expression of the androgen receptor (AR) in luminal cells of human BPH specimens correlates with a higher degree of regional prostatic inflammation. However, the cause-and-effect re...

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Veröffentlicht in:	Molecular cell 2016-09, Vol.63 (6), p.976-989
Hauptverfasser:	Zhang, Boyu, Kwon, Oh-Joon, Henry, Gervaise, Malewska, Alicia, Wei, Xing, Zhang, Li, Brinkley, William, Zhang, Yiqun, Castro, Patricia D., Titus, Mark, Chen, Rui, Sayeeduddin, Mohammad, Raj, Ganesh V., Mauck, Ryan, Roehrborn, Claus, Creighton, Chad J., Strand, Douglas W., Ittmann, Michael M., Xin, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor androgen receptors animal models Animals benign prostatic hyperplasia Cell Proliferation Chemokine CCL2 - genetics Chemokine CCL2 - immunology Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology chemokines Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology epithelial homeostasis epithelium etiology Gene Expression Regulation homeostasis Homeostasis - genetics Homeostasis - immunology Humans hyperplasia Inflammation interleukin-1 Interleukin-1alpha - genetics Interleukin-1alpha - immunology Interleukin-1beta - genetics Interleukin-1beta - immunology Leukocyte Common Antigens - genetics Leukocyte Common Antigens - immunology macrophage macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Mice microenvironment Neutrophil Infiltration Prostate - immunology Prostate - metabolism Prostate - pathology Prostatic Hyperplasia - genetics Prostatic Hyperplasia - immunology Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Receptors, Androgen - genetics Receptors, Androgen - immunology Signal Transduction Stromal Cells - immunology Stromal Cells - metabolism Stromal Cells - pathology therapeutics
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