Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways

Inhibition of angiogenesis is considered as one of the desirable pathways for the treatment of tumor growth and metastasis. Herein we demonstrated that a series of pyridinyl-thiazolyl carboxamide derivatives were designed, synthesized and examined against angiogenesis through a colony formation and...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.33434-33434, Article 33434
Hauptverfasser:	Zhou, Wenbo, Tang, Wenshu, Sun, Zhenliang, Li, Yunqi, Dong, Yanmin, Pei, Haixiang, Peng, Yangrui, Wang, Jinhua, Shao, Ting, Jiang, Zhenran, Yi, Zhengfang, Chen, Yihua
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1435/2417 631/154/309/2419 96/98 Angiogenesis Angiogenesis inhibitors Animals Antifungal agents Aorta Cancer Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chick Embryo Chorioallantoic membrane Colonies Colony-Forming Units Assay Drug Design Drug Discovery Endothelial cells Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Male Metastases Mice, Nude multidisciplinary Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - pathology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Phosphorylation - drug effects Piperidines - pharmacology Piperidines - therapeutic use Quinazolines - pharmacology Quinazolines - therapeutic use Rats, Sprague-Dawley Science Signal Transduction Stress Fibers - drug effects Stress Fibers - metabolism Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Thiazoles - therapeutic use Umbilical vein Vascular endothelial growth factor Wound Healing - drug effects
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