Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

Microrchidia (MORC) proteins are GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPases that function in gene regulation in multiple organisms. Animal MORCs also contain CW-type zinc finger domains, which are known to bind to modified histones. We solved the crystal structure of the mu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-08, Vol.113 (35), p.E5108-E5116
Hauptverfasser:	Li, Sisi, Yen, Linda, Pastor, William A., Johnston, Jonathan B., Du, Jiamu, Shew, Colin J., Liu, Wanlu, Ho, Jamie, Stender, Bryan, Clark, Amander T., Burlingame, Alma L., Daxinger, Lucia, Patel, Dinshaw J., Jacobsen, Steven E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenylyl Imidodiphosphate - chemistry Adenylyl Imidodiphosphate - metabolism Animals Biological Sciences Chromatin - genetics Chromatin - metabolism Crystal structure Crystallography, X-Ray DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genomes Histones - chemistry Histones - genetics Histones - metabolism Hydrogen bonds Lysine - chemistry Lysine - genetics Lysine - metabolism Mass spectrometry Methylation Mice Models, Molecular PNAS Plus Promoter Regions, Genetic - genetics Protein Binding Protein Domains Protein Multimerization Proteins Zinc Fingers
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