Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders
The plasma of patients with myeloproliferative diseases was examined by polyethylene glycol (PEG) precipitation, analytical ultracentrifugation, and immunoaffinity chromatography for the presence of high molecular weight complexes of IgG and fibronectin. Abnormal circulating high molecular weight ma...
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| Veröffentlicht in: | Journal of clinical pathology 1990-02, Vol.43 (2), p.102-105 |
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| container_title | Journal of clinical pathology |
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| creator | Baglin, T P Price, S M Boughton, B J |
| description | The plasma of patients with myeloproliferative diseases was examined by polyethylene glycol (PEG) precipitation, analytical ultracentrifugation, and immunoaffinity chromatography for the presence of high molecular weight complexes of IgG and fibronectin. Abnormal circulating high molecular weight material was identified by ultracentrifugation in all patients. This was precipitated by PEG and was shown by exclusion chromatography to contain IgG in a high molecular weight form. Examination of plasma by immunoaffinity chromatography supported previous evidence for complex formation between IgG and fibronectin. These findings are further evidence that abnormal high molecular weight IgG complexes are a prominent feature of myeloproliferative disorders and implicate IgG fibronectin complex formation. |
| doi_str_mv | 10.1136/jcp.43.2.102 |
| format | Article |
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Abnormal circulating high molecular weight material was identified by ultracentrifugation in all patients. This was precipitated by PEG and was shown by exclusion chromatography to contain IgG in a high molecular weight form. Examination of plasma by immunoaffinity chromatography supported previous evidence for complex formation between IgG and fibronectin. These findings are further evidence that abnormal high molecular weight IgG complexes are a prominent feature of myeloproliferative disorders and implicate IgG fibronectin complex formation.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.43.2.102</identifier><identifier>PMID: 2318985</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Antigen-Antibody Complex - analysis ; Biological and medical sciences ; Chromatography, Affinity ; Chromatography, Gel ; Fibronectins - analysis ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulin G - analysis ; Medical sciences ; Molecular Weight ; Myeloproliferative Disorders - immunology ; Polycythemia Vera - immunology ; Primary Myelofibrosis - immunology</subject><ispartof>Journal of clinical pathology, 1990-02, Vol.43 (2), p.102-105</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Feb 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b505t-a402f6b751d10d49c42baecea1f68d71aa65db9d1db29356b628d7adc2ea04c13</citedby><cites>FETCH-LOGICAL-b505t-a402f6b751d10d49c42baecea1f68d71aa65db9d1db29356b628d7adc2ea04c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC502288/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC502288/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4364067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2318985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baglin, T P</creatorcontrib><creatorcontrib>Price, S M</creatorcontrib><creatorcontrib>Boughton, B J</creatorcontrib><title>Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>The plasma of patients with myeloproliferative diseases was examined by polyethylene glycol (PEG) precipitation, analytical ultracentrifugation, and immunoaffinity chromatography for the presence of high molecular weight complexes of IgG and fibronectin. Abnormal circulating high molecular weight material was identified by ultracentrifugation in all patients. This was precipitated by PEG and was shown by exclusion chromatography to contain IgG in a high molecular weight form. Examination of plasma by immunoaffinity chromatography supported previous evidence for complex formation between IgG and fibronectin. These findings are further evidence that abnormal high molecular weight IgG complexes are a prominent feature of myeloproliferative disorders and implicate IgG fibronectin complex formation.</description><subject>Antigen-Antibody Complex - analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Affinity</subject><subject>Chromatography, Gel</subject><subject>Fibronectins - analysis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Medical sciences</subject><subject>Molecular Weight</subject><subject>Myeloproliferative Disorders - immunology</subject><subject>Polycythemia Vera - immunology</subject><subject>Primary Myelofibrosis - immunology</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtv1DAUhS1EVaaFHVukSKCyaQbbcexkwQKNoPQFQuKxYGE59s2Mp04c7KS0_x6PZjQqLFhZ95zvXh3rIPSc4DkhBX-z1sOcFXM6J5g-QjPCBM0ZYfwxmmFMSV4Lxp-goxjXGJNCkOIQHdKCVHVVztDPhQ16cmq0_TJb2eUq67yDjRKy35DmMTtfnmWtbYLvQScs074bHNxBzNLQ3YPzQ_DOthDSlVvIjI0-GAjxKTpolYvwbPceo28f3n9dfMyvPp-dL95d5U2JyzFXDNOWN6IkhmDDas1oo0CDIi2vjCBK8dI0tSGmoXVR8obTJCujKSjMNCmO0dvt3WFqOjAa-jEoJ4dgOxXupVdW_u30diWX_laWmNKqSvsnu_3gf00QR9nZqME51YOfohQ1r4mo6wS-_Adc-yn06W-SCIEZ47jaUKdbSgcfY4B2n4RguWlMpsYkKyRNAk34i4fp9_CuouS_2vkqauXaoHpt4x5jBWeYi4TlW8zGEe72tgo3MrmilJ--L-TlxZfLkv-4lteJf73lm279_4B_AFsmvRI</recordid><startdate>19900201</startdate><enddate>19900201</enddate><creator>Baglin, T P</creator><creator>Price, S M</creator><creator>Boughton, B J</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900201</creationdate><title>Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders</title><author>Baglin, T P ; Price, S M ; Boughton, B J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b505t-a402f6b751d10d49c42baecea1f68d71aa65db9d1db29356b628d7adc2ea04c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antigen-Antibody Complex - analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Affinity</topic><topic>Chromatography, Gel</topic><topic>Fibronectins - analysis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Medical sciences</topic><topic>Molecular Weight</topic><topic>Myeloproliferative Disorders - immunology</topic><topic>Polycythemia Vera - immunology</topic><topic>Primary Myelofibrosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baglin, T P</creatorcontrib><creatorcontrib>Price, S M</creatorcontrib><creatorcontrib>Boughton, B J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baglin, T P</au><au>Price, S M</au><au>Boughton, B J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>1990-02-01</date><risdate>1990</risdate><volume>43</volume><issue>2</issue><spage>102</spage><epage>105</epage><pages>102-105</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>The plasma of patients with myeloproliferative diseases was examined by polyethylene glycol (PEG) precipitation, analytical ultracentrifugation, and immunoaffinity chromatography for the presence of high molecular weight complexes of IgG and fibronectin. Abnormal circulating high molecular weight material was identified by ultracentrifugation in all patients. This was precipitated by PEG and was shown by exclusion chromatography to contain IgG in a high molecular weight form. Examination of plasma by immunoaffinity chromatography supported previous evidence for complex formation between IgG and fibronectin. These findings are further evidence that abnormal high molecular weight IgG complexes are a prominent feature of myeloproliferative disorders and implicate IgG fibronectin complex formation.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>2318985</pmid><doi>10.1136/jcp.43.2.102</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigen-Antibody Complex - analysis Biological and medical sciences Chromatography, Affinity Chromatography, Gel Fibronectins - analysis Hematologic and hematopoietic diseases Humans Immunoglobulin G - analysis Medical sciences Molecular Weight Myeloproliferative Disorders - immunology Polycythemia Vera - immunology Primary Myelofibrosis - immunology |
| title | Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders |
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