The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling

Aim： Psm2, one of the pyrrolidinoindoline alkaloids isolated from whole Selaginella moellendorffii plants, has shown a potent antiplatelet activity. In this study, we further evaluated the antiplatelet effects of Psm2, and elucidated the underlying mechanisms. Methods： Human platelet aggregation in...

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Veröffentlicht in:	Acta pharmacologica Sinica 2016-09, Vol.37 (9), p.1208-1217
Hauptverfasser:	Su, Xing-li, Su, Wen, Wang, Ying, Wang, Yue-hu, Ming, Xin, Kong, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - adverse effects Alkaloids - isolation & purification Alkaloids - pharmacology Alkaloids - therapeutic use Animals Biomedical and Life Sciences Biomedicine Blood Platelets - cytology Blood Platelets - drug effects Disease Models, Animal Dose-Response Relationship, Drug Humans Immunology Indole Alkaloids - adverse effects Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Indole Alkaloids - therapeutic use Internal Medicine Medical Microbiology Mice, Inbred ICR Molecular Docking Simulation Molecular Structure Original original-article Pharmacology/Toxicology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - isolation & purification Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Protein Binding Proto-Oncogene Proteins c-akt - antagonists & inhibitors Rats, Sprague-Dawley Selaginella Selaginellaceae - chemistry Thrombosis - blood Thrombosis - drug therapy Thrombosis - metabolism Vaccine
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