Thiol dependent intramolecular locking of Orai1 channels

Store-operated Ca 2+ entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and other pathologies. Reactive oxygen species interacting with cysteine residues can alter protein function. Pretreatment of...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.33347-33347, Article 33347
Hauptverfasser:	Alansary, Dalia, Schmidt, Barbara, Dörr, Kathrin, Bogeski, Ivan, Rieger, Heiko, Kless, Achim, Niemeyer, Barbara A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/470/1463 631/92/269/1146 Biophysics Calcium channels Calcium influx Cysteine Enzymes Gene expression HEK293 Cells Humanities and Social Sciences Humans Mesylates - metabolism Microscopy multidisciplinary Mutation - genetics Neoplasm Proteins - metabolism Orai1 protein ORAI1 Protein - antagonists & inhibitors ORAI1 Protein - metabolism Oxidation Oxidation-Reduction Oxidizing agents Prostate Protein Binding Protein Subunits - metabolism Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Science Sensors Serine - metabolism STIM1 protein Stromal Interaction Molecule 1 - metabolism Sulfhydryl Compounds - metabolism
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