Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo

Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella upon primary infection and zoster upon reactivation from latency in sensory ganglion neurons. The replication of herpesviruses requires manipulation of cell signaling pathways. Notably, CREB, a factor involved in the regulatio...

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Veröffentlicht in:	Journal of virology 2016-10, Vol.90 (19), p.8686-8697
Hauptverfasser:	François, Sylvie, Sen, Nandini, Mitton, Bryan, Xiao, Xiangshu, Sakamoto, Kathleen M, Arvin, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal E1A-Associated p300 Protein - metabolism Herpes Zoster - pathology Herpes Zoster - virology Herpesvirus 3, Human - physiology Host-Pathogen Interactions Humans Mice, SCID Peptide Fragments - metabolism Phosphorylation Protein Processing, Post-Translational Sialoglycoproteins - metabolism Skin - pathology Virus Replication Virus-Cell Interactions
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