Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination

Background. Influenza A(H5N1) virus and other avian influenza virus strains represent major pandemic threats. Like all influenza A virus strains, A(H5N1) viruses evolve rapidly. Innovative immunization strategies are needed to induce cross-protective immunity. Methods. Subjects primed with clade 1 H...

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Veröffentlicht in:	The Journal of infectious diseases 2016-10, Vol.214 (7), p.1020-1029
Hauptverfasser:	Hoft, Daniel F., Lottenbach, Kathleen, Goll, Johannes B., Hill, Heather, Winokur, Patricia L., Patel, Shital M., Brady, Rebecca C., Chen, Wilbur H., Edwards, Kathryn, Creech, C. Buddy, Frey, Sharon E., Blevins, Tamara P., Salomon, Rachelle, Belshe, Robert B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cell Proliferation Cytokines - secretion Double-Blind Method Female Hemagglutinin Glycoproteins, Influenza Virus - administration & dosage Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immunity, Heterologous Influenza A virus Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - prevention & control Major and Brief Reports Male Middle Aged Orthomyxoviridae T-Lymphocytes - immunology Vaccination - methods VIRUSES Young Adult
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