Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

Joseph Gleeson and colleagues report whole-exome sequencing of a cohort of over 1,000 individuals from the Greater Middle East, characterizing common and rare variants. They find evidence of subregional diversity and historical migrations and use the GME Variome to identify disease-causing mutations...

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Veröffentlicht in:	Nature genetics 2016-09, Vol.48 (9), p.1071-1076
Hauptverfasser:	Scott, Eric M, Halees, Anason, Itan, Yuval, Spencer, Emily G, He, Yupeng, Azab, Mostafa Abdellateef, Gabriel, Stacey B, Belkadi, Aziz, Boisson, Bertrand, Abel, Laurent, Clark, Andrew G, Alkuraya, Fowzan S, Casanova, Jean-Laurent, Gleeson, Joseph G
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 631/208/457 692/700/478/174 Agriculture Animal Genetics and Genomics Arabs Asian People - genetics Biomedicine Cancer Research Cohort Studies Consanguinity Consortia Disease - genetics Exome - genetics Exome sequencing Gene Function Genes, Recessive Genetic aspects Genetic diversity Genetic Markers - genetics Genetic research Genetic susceptibility Genetic Variation - genetics Genetics Genetics, Population Genome, Human Genome-Wide Association Study Genomes Genotypes Health aspects Hominids Homozygosity Homozygote Human Genetics Human Migration Humans Identification and classification letter Methods Middle East Population Population genetics White People - genetics
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