Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs
Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apopt...
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| Veröffentlicht in: | Chinese journal of cancer research 2016-08, Vol.28 (4), p.383-396 |
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| creator | Ivanova, Donika Zhelev, Zhivko Aoki, Ichio Bakalova, Rumiana Higashi, Tatsuya |
| description | Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS~independent pathways. We try to answer the question： ＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. |
| doi_str_mv | 10.21147/j.issn.1000-9604.2016.04.01 |
| format | Article |
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It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS~independent pathways. We try to answer the question： ＂Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues？＂ The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.</description><identifier>ISSN: 1000-9604</identifier><identifier>EISSN: 1993-0631</identifier><identifier>DOI: 10.21147/j.issn.1000-9604.2016.04.01</identifier><identifier>PMID: 27647966</identifier><language>eng</language><publisher>China: Medical Faculty, Sofia University, Sofia 1407, Bulgaria</publisher><subject>Review ; 强制性 ; 抗癌药物 ; 正常细胞 ; 氧化还原平衡 ; 活性氧物种 ; 生产 ; 细胞凋亡 ; 诱导</subject><ispartof>Chinese journal of cancer research, 2016-08, Vol.28 (4), p.383-396</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright © 2016 Chinese Journal of Cancer Research. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-394cc864470e3acdebfed52940594f10188f4b8a481ad251550fc255fed549633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85190X/85190X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018533/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018533/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27647966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanova, Donika</creatorcontrib><creatorcontrib>Zhelev, Zhivko</creatorcontrib><creatorcontrib>Aoki, Ichio</creatorcontrib><creatorcontrib>Bakalova, Rumiana</creatorcontrib><creatorcontrib>Higashi, Tatsuya</creatorcontrib><creatorcontrib>Institute of Biophysics & Biomedical Engineering, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria</creatorcontrib><creatorcontrib>Medical Faculty, Trakia University, Stara Zagora 6000, Bulgaria</creatorcontrib><creatorcontrib>Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan</creatorcontrib><creatorcontrib>Medical Faculty, Sofia University, Sofia 1407, Bulgaria</creatorcontrib><title>Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs</title><title>Chinese journal of cancer research</title><addtitle>Chinese Journal of Cancer Research</addtitle><description>Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species （ROS） and alter redox-homeostasis of cancer cells. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Review 强制性 抗癌药物 正常细胞 氧化还原平衡 活性氧物种 生产 细胞凋亡 诱导 |
| title | Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs |
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