BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolutely required for this process. Here, we report that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MO...

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Veröffentlicht in:	Cell 2016-04, Vol.165 (2), p.421-433
Hauptverfasser:	Llambi, Fabien, Wang, Yue-Ming, Victor, Bernadette, Yang, Mao, Schneider, Desiree M., Gingras, Sébastien, Parsons, Melissa J., Zheng, Janet H., Brown, Scott A., Pelletier, Stéphane, Moldoveanu, Tudor, Chen, Taosheng, Green, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis cell viability Embryo, Mammalian - cytology Embryo, Mammalian - metabolism endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum-Associated Degradation Fibroblasts - metabolism Humans Mice mitochondria mitochondrial membrane Mitochondrial Membranes - metabolism Permeability proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism ubiquitin-protein ligase
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