Phenotypic and Functional Comparison of Class Switch Recombination Deficiencies with a Subgroup of Common Variable Immunodeficiencies

Primary antibody deficiencies (PADs) are the most common immunodeficiency in humans, characterized by low levels of immunoglobulins and inadequate antibody responses upon immunization. These PADs may result from an early block in B cell development with a complete absence of peripheral B cells and l...

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Veröffentlicht in:	Journal of clinical immunology 2016-10, Vol.36 (7), p.656-666
Hauptverfasser:	aan de Kerk, Daan J., Jansen, Machiel H., Jolles, Stephen, Warnatz, Klaus, Seneviratne, Suranjith L., ten Berge, Ineke J. M., van Leeuwen, Ester M. M., Kuijpers, Taco W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomarkers Biomedical and Life Sciences Biomedicine Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - genetics Common Variable Immunodeficiency - immunology Female Genetic Predisposition to Disease Humans Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M - blood Immunoglobulin M - immunology Immunology Immunophenotyping Infectious Diseases Internal Medicine Lymphocyte Activation - immunology Male Medical Microbiology Middle Aged Original Original Article Phenotype Plasma Cells - immunology Plasma Cells - metabolism Plasma Cells - pathology Young Adult
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