Identification of a Legionella pneumophila Locus Required for Intracellular Multiplication in Human Macrophages

The legionnaires' disease bacterium, Legionella pneumophila, is a facultative intracellular parasite. Its interaction with phagocytes has characteristics in common with several other intracellular parasites. Critical aspects of L. pneumophila intracellular multiplication are evasion of lysosoma...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-10, Vol.89 (20), p.9607-9611
Hauptverfasser:	Marra, Andrea, Blander, Steven J., Horwitz, Marcus A., Shuman, Howard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacteria Cellular biology Disease DNA, Bacterial - genetics Genes, Bacterial Genetic Complementation Test Genetic loci Guinea Pigs Hematopoietic stem cells In Vitro Techniques Infections Intracellular Membranes Legionella pneumophila Legionella pneumophila - genetics Legionella pneumophila - growth & development Legionella pneumophila - pathogenicity Lysosomes Macrophages Macrophages - microbiology Membrane Fusion Phagocytes Phagocytosis Phagosomes Plasmids Restriction Mapping Tumor Cells, Cultured
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