Perimetry, Retinal Nerve Fiber Layer Thickness and Papilledema Grade After Cerebrospinal Fluid Shunting in Patients With Idiopathic Intracranial Hypertension
BACKGROUND:To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH). METHODS:We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 20...
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| Veröffentlicht in: | Journal of neuro-ophthalmology 2015-03, Vol.35 (1), p.22-25 |
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| creator | Rizzo, Jennifer L Lam, Khoa V Wall, Michael Wilson, Machelle D Keltner, John L |
| description | BACKGROUND:To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH).
METHODS:We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention.
RESULTS:Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001).
CONCLUSIONS:Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH. |
| doi_str_mv | 10.1097/WNO.0000000000000181 |
| format | Article |
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METHODS:We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention.
RESULTS:Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001).
CONCLUSIONS:Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH.</description><identifier>ISSN: 1070-8022</identifier><identifier>EISSN: 1536-5166</identifier><identifier>DOI: 10.1097/WNO.0000000000000181</identifier><identifier>PMID: 25295682</identifier><language>eng</language><publisher>United States: by North American Neuro-Ophthalmology Society</publisher><subject>Adolescent ; Adult ; Aged ; Cerebrospinal Fluid Shunts - methods ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers - pathology ; Papilledema - etiology ; Papilledema - surgery ; Pseudotumor Cerebri - complications ; Pseudotumor Cerebri - surgery ; Retina - pathology ; Retrospective Studies ; Treatment Outcome ; Vision Disorders - etiology ; Vision Disorders - surgery ; Visual Field Tests - methods ; Young Adult</subject><ispartof>Journal of neuro-ophthalmology, 2015-03, Vol.35 (1), p.22-25</ispartof><rights>2015 by North American Neuro-Ophthalmology Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4901-dd01f73357763c95db7c11a7b096fc8a74118557c8beca102042f2c855fead4f3</citedby><cites>FETCH-LOGICAL-c4901-dd01f73357763c95db7c11a7b096fc8a74118557c8beca102042f2c855fead4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25295682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rizzo, Jennifer L</creatorcontrib><creatorcontrib>Lam, Khoa V</creatorcontrib><creatorcontrib>Wall, Michael</creatorcontrib><creatorcontrib>Wilson, Machelle D</creatorcontrib><creatorcontrib>Keltner, John L</creatorcontrib><title>Perimetry, Retinal Nerve Fiber Layer Thickness and Papilledema Grade After Cerebrospinal Fluid Shunting in Patients With Idiopathic Intracranial Hypertension</title><title>Journal of neuro-ophthalmology</title><addtitle>J Neuroophthalmol</addtitle><description>BACKGROUND:To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH).
METHODS:We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention.
RESULTS:Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001).
CONCLUSIONS:Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Cerebrospinal Fluid Shunts - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Papilledema - etiology</subject><subject>Papilledema - surgery</subject><subject>Pseudotumor Cerebri - complications</subject><subject>Pseudotumor Cerebri - surgery</subject><subject>Retina - pathology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Vision Disorders - etiology</subject><subject>Vision Disorders - surgery</subject><subject>Visual Field Tests - methods</subject><subject>Young Adult</subject><issn>1070-8022</issn><issn>1536-5166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhi0EoqXwBgj5yIEU24nj5IJUrdh2pVVbQVGPlmNPGlOvk9pOq30Y3hWXLVXhgPDBHtn__2k8Mwi9peSQklZ8vDw9OyRPF23oM7RPeVkXnNb18xwTQYqGMLaHXsX4PWtKwtqXaI9x1vK6YfvoxzkEu4EUth_wF0jWK4dPIdwCXtoOAl6rbd4vBquvPcSIlTf4XE3WOTCwUfg4KAP4qE9ZtYAAXRjj9IuydLM1-Osw-0y9wtZnX7LgU8SXNg14Zew4qZTJeOVTUDoob7PvZDtBSOCjHf1r9KJXLsKbh_MAfVt-vlicFOuz49XiaF3oqiW0MIbQXpQlF6IudctNJzSlSnSkrXvdKFFR2nAudNOBVpQwUrGe6XzVgzJVXx6gTzvuNHcbMBruE3JyyqVRYStHZeWfL94O8mq8lZxQwSqRAe8fAGG8mSEmubFRg3PKwzhHSeuGVLwuafkfUs45I7k_WVrtpDpXNQboHzOiRN4PgcxDIP8egmx79_Q3j6bfXc-CZie4G11uXLx28x0EOYByafg3-ye0mMFv</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Rizzo, Jennifer L</creator><creator>Lam, Khoa V</creator><creator>Wall, Michael</creator><creator>Wilson, Machelle D</creator><creator>Keltner, John L</creator><general>by North American Neuro-Ophthalmology Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201503</creationdate><title>Perimetry, Retinal Nerve Fiber Layer Thickness and Papilledema Grade After Cerebrospinal Fluid Shunting in Patients With Idiopathic Intracranial Hypertension</title><author>Rizzo, Jennifer L ; Lam, Khoa V ; Wall, Michael ; Wilson, Machelle D ; Keltner, John L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4901-dd01f73357763c95db7c11a7b096fc8a74118557c8beca102042f2c855fead4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Cerebrospinal Fluid Shunts - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Papilledema - etiology</topic><topic>Papilledema - surgery</topic><topic>Pseudotumor Cerebri - complications</topic><topic>Pseudotumor Cerebri - surgery</topic><topic>Retina - pathology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Vision Disorders - etiology</topic><topic>Vision Disorders - surgery</topic><topic>Visual Field Tests - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizzo, Jennifer L</creatorcontrib><creatorcontrib>Lam, Khoa V</creatorcontrib><creatorcontrib>Wall, Michael</creatorcontrib><creatorcontrib>Wilson, Machelle D</creatorcontrib><creatorcontrib>Keltner, John L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuro-ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizzo, Jennifer L</au><au>Lam, Khoa V</au><au>Wall, Michael</au><au>Wilson, Machelle D</au><au>Keltner, John L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perimetry, Retinal Nerve Fiber Layer Thickness and Papilledema Grade After Cerebrospinal Fluid Shunting in Patients With Idiopathic Intracranial Hypertension</atitle><jtitle>Journal of neuro-ophthalmology</jtitle><addtitle>J Neuroophthalmol</addtitle><date>2015-03</date><risdate>2015</risdate><volume>35</volume><issue>1</issue><spage>22</spage><epage>25</epage><pages>22-25</pages><issn>1070-8022</issn><eissn>1536-5166</eissn><abstract>BACKGROUND:To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH).
METHODS:We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention.
RESULTS:Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001).
CONCLUSIONS:Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH.</abstract><cop>United States</cop><pub>by North American Neuro-Ophthalmology Society</pub><pmid>25295682</pmid><doi>10.1097/WNO.0000000000000181</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Aged Cerebrospinal Fluid Shunts - methods Female Humans Male Middle Aged Nerve Fibers - pathology Papilledema - etiology Papilledema - surgery Pseudotumor Cerebri - complications Pseudotumor Cerebri - surgery Retina - pathology Retrospective Studies Treatment Outcome Vision Disorders - etiology Vision Disorders - surgery Visual Field Tests - methods Young Adult |
| title | Perimetry, Retinal Nerve Fiber Layer Thickness and Papilledema Grade After Cerebrospinal Fluid Shunting in Patients With Idiopathic Intracranial Hypertension |
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