A Role for the Inflammasome in Spontaneous Labor at Term
Problem Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of this study were to determine (i) the expression of major inflammasome components in the chorioamniotic membranes in spon...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2018-06, Vol.79 (6), p.e12440-n/a |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Romero, Roberto Xu, Yi Plazyo, Olesya Chaemsaithong, Piya Chaiworapongsa, Tinnakorn Unkel, Ronald Than, Nandor Gabor Chiang, Po Jen Dong, Zhong Xu, Zhonghui Tarca, Adi L. Abrahams, Vikki M. Hassan, Sonia S. Yeo, Lami Gomez‐Lopez, Nardhy |
| description | Problem
Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of this study were to determine (i) the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term, (ii) whether there are changes in the inflammasome components associated with the activation of caspase‐1 and caspase‐4, and (iii) whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
Method of study
Chorioamniotic membranes were collected from women at term with and without spontaneous labor. mRNA abundance and protein concentrations of inflammasome components, nucleotide‐binding oligomerization domain‐containing (NOD)1 and NOD2 proteins, caspase‐1, caspase‐4, IL‐1β, and IL‐18 were quantified by qRT‐PCR (n = 28–29 each), ELISA (n = 10 each) or immunoblotting (n = 8 each), and immunohistochemistry (n = 10 each). Active caspase‐1 and caspase‐4, as well as mature IL‐18, were determined by immunoblotting (n = 4 each), and pro‐ and mature forms of IL‐1β were determined by ELISA (n = 4–7 each).
Results
Inflammasome components and NOD proteins were expressed in the chorioamniotic membranes obtained from women at term. The chorioamniotic membranes from women who underwent labor had (i) higher concentrations of NLRP3 (NOD‐like receptor family, pyrin domain‐containing protein 3) and NOD1 protein, (ii) greater immunoreactivity for caspase‐1 and caspase‐4, (iii) a greater quantity of the active form of caspase‐1 (p20), and (iv) higher mRNA abundance and protein concentrations of pro‐ and mature IL‐1β. However, mRNA abundance and protein concentrations of the mature form of IL‐18 were not increased in tissues from women who underwent labor at term.
Conclusions
Spontaneous labor at term is characterized by the expression of inflammasome components, which may participate in the activation of caspase‐1 and lead to the cleavage and release of mature IL‐1β by the chorioamniotic membranes. These results support the participation of the inflammasome in the mechanisms responsible for spontaneous parturition at term. |
| doi_str_mv | 10.1111/aji.12440 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5016201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1826661235</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5090-23715f7542ea18f5f31ed9cea27bb305aa7f547da45ae2468ed88b05012c5aff3</originalsourceid><addsrcrecordid>eNp1kU1P3DAQhq2KqnyUQ_9AFYlLOQTGju04F6QV4mPRSpVaOFuT7LhklcRbO1vEv8clgAAJX8aaefRoRi9j3zgc8fSOcdUecSElfGI7XAPkYKpyK_1B6ryUYLbZbowrgNQvyi9sW-hKiULzHWZm2S_fUeZ8yMZbyuaD67DvMfqesnbIfq_9MOJAfhOzBdaJwjG7ptB_ZZ8ddpH2n-oeuzk_uz69zBc_L-ans0XeKKggF0XJlSuVFITcOOUKTsuqIRRlXRegEEunZLlEqZCE1IaWxtSggItGoXPFHjuZvOtN3dOyoWEM2Nl1aHsM99Zja99OhvbW_vH_bFJoATwJfjwJgv-7oTjavo0Ndd10leVGaK25KFRCD96hK78JQzrPCih0VRlQMlGHE9UEH2Mg97IMB_s_D5vysI95JPb76-1fyOcAEnA8AXdtR_cfm-zsaj4pHwAEkpL2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036998054</pqid></control><display><type>article</type><title>A Role for the Inflammasome in Spontaneous Labor at Term</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Romero, Roberto ; Xu, Yi ; Plazyo, Olesya ; Chaemsaithong, Piya ; Chaiworapongsa, Tinnakorn ; Unkel, Ronald ; Than, Nandor Gabor ; Chiang, Po Jen ; Dong, Zhong ; Xu, Zhonghui ; Tarca, Adi L. ; Abrahams, Vikki M. ; Hassan, Sonia S. ; Yeo, Lami ; Gomez‐Lopez, Nardhy</creator><creatorcontrib>Romero, Roberto ; Xu, Yi ; Plazyo, Olesya ; Chaemsaithong, Piya ; Chaiworapongsa, Tinnakorn ; Unkel, Ronald ; Than, Nandor Gabor ; Chiang, Po Jen ; Dong, Zhong ; Xu, Zhonghui ; Tarca, Adi L. ; Abrahams, Vikki M. ; Hassan, Sonia S. ; Yeo, Lami ; Gomez‐Lopez, Nardhy</creatorcontrib><description>Problem
Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of this study were to determine (i) the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term, (ii) whether there are changes in the inflammasome components associated with the activation of caspase‐1 and caspase‐4, and (iii) whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
Method of study
Chorioamniotic membranes were collected from women at term with and without spontaneous labor. mRNA abundance and protein concentrations of inflammasome components, nucleotide‐binding oligomerization domain‐containing (NOD)1 and NOD2 proteins, caspase‐1, caspase‐4, IL‐1β, and IL‐18 were quantified by qRT‐PCR (n = 28–29 each), ELISA (n = 10 each) or immunoblotting (n = 8 each), and immunohistochemistry (n = 10 each). Active caspase‐1 and caspase‐4, as well as mature IL‐18, were determined by immunoblotting (n = 4 each), and pro‐ and mature forms of IL‐1β were determined by ELISA (n = 4–7 each).
Results
Inflammasome components and NOD proteins were expressed in the chorioamniotic membranes obtained from women at term. The chorioamniotic membranes from women who underwent labor had (i) higher concentrations of NLRP3 (NOD‐like receptor family, pyrin domain‐containing protein 3) and NOD1 protein, (ii) greater immunoreactivity for caspase‐1 and caspase‐4, (iii) a greater quantity of the active form of caspase‐1 (p20), and (iv) higher mRNA abundance and protein concentrations of pro‐ and mature IL‐1β. However, mRNA abundance and protein concentrations of the mature form of IL‐18 were not increased in tissues from women who underwent labor at term.
Conclusions
Spontaneous labor at term is characterized by the expression of inflammasome components, which may participate in the activation of caspase‐1 and lead to the cleavage and release of mature IL‐1β by the chorioamniotic membranes. These results support the participation of the inflammasome in the mechanisms responsible for spontaneous parturition at term.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12440</identifier><identifier>PMID: 26952361</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Amnion - metabolism ; Caspase ; Caspase 1 - metabolism ; caspase‐1 ; chorioamniotic membranes ; Enzyme-linked immunosorbent assay ; Female ; Humans ; IL-1β ; Immunoblotting ; Immunohistochemistry ; Inflammasomes ; Inflammasomes - metabolism ; Inflammation - metabolism ; Interleukin-18 - metabolism ; Interleukin-1beta - metabolism ; Labor, Obstetric - metabolism ; mRNA ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; NLRP3 ; Nod1 protein ; Nod1 Signaling Adaptor Protein - metabolism ; NOD2 protein ; Oligomerization ; Parturition ; Pregnancy ; Proteins ; Pyrin protein ; sterile inflammation ; Young Adult</subject><ispartof>American journal of reproductive immunology (1989), 2018-06, Vol.79 (6), p.e12440-n/a</ispartof><rights>Published 2016. This article is a U.S. Government work and is in the public domain in the USA.</rights><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5090-23715f7542ea18f5f31ed9cea27bb305aa7f547da45ae2468ed88b05012c5aff3</citedby><cites>FETCH-LOGICAL-c5090-23715f7542ea18f5f31ed9cea27bb305aa7f547da45ae2468ed88b05012c5aff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12440$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12440$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26952361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Plazyo, Olesya</creatorcontrib><creatorcontrib>Chaemsaithong, Piya</creatorcontrib><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Unkel, Ronald</creatorcontrib><creatorcontrib>Than, Nandor Gabor</creatorcontrib><creatorcontrib>Chiang, Po Jen</creatorcontrib><creatorcontrib>Dong, Zhong</creatorcontrib><creatorcontrib>Xu, Zhonghui</creatorcontrib><creatorcontrib>Tarca, Adi L.</creatorcontrib><creatorcontrib>Abrahams, Vikki M.</creatorcontrib><creatorcontrib>Hassan, Sonia S.</creatorcontrib><creatorcontrib>Yeo, Lami</creatorcontrib><creatorcontrib>Gomez‐Lopez, Nardhy</creatorcontrib><title>A Role for the Inflammasome in Spontaneous Labor at Term</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of this study were to determine (i) the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term, (ii) whether there are changes in the inflammasome components associated with the activation of caspase‐1 and caspase‐4, and (iii) whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
Method of study
Chorioamniotic membranes were collected from women at term with and without spontaneous labor. mRNA abundance and protein concentrations of inflammasome components, nucleotide‐binding oligomerization domain‐containing (NOD)1 and NOD2 proteins, caspase‐1, caspase‐4, IL‐1β, and IL‐18 were quantified by qRT‐PCR (n = 28–29 each), ELISA (n = 10 each) or immunoblotting (n = 8 each), and immunohistochemistry (n = 10 each). Active caspase‐1 and caspase‐4, as well as mature IL‐18, were determined by immunoblotting (n = 4 each), and pro‐ and mature forms of IL‐1β were determined by ELISA (n = 4–7 each).
Results
Inflammasome components and NOD proteins were expressed in the chorioamniotic membranes obtained from women at term. The chorioamniotic membranes from women who underwent labor had (i) higher concentrations of NLRP3 (NOD‐like receptor family, pyrin domain‐containing protein 3) and NOD1 protein, (ii) greater immunoreactivity for caspase‐1 and caspase‐4, (iii) a greater quantity of the active form of caspase‐1 (p20), and (iv) higher mRNA abundance and protein concentrations of pro‐ and mature IL‐1β. However, mRNA abundance and protein concentrations of the mature form of IL‐18 were not increased in tissues from women who underwent labor at term.
Conclusions
Spontaneous labor at term is characterized by the expression of inflammasome components, which may participate in the activation of caspase‐1 and lead to the cleavage and release of mature IL‐1β by the chorioamniotic membranes. These results support the participation of the inflammasome in the mechanisms responsible for spontaneous parturition at term.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amnion - metabolism</subject><subject>Caspase</subject><subject>Caspase 1 - metabolism</subject><subject>caspase‐1</subject><subject>chorioamniotic membranes</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Humans</subject><subject>IL-1β</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Inflammasomes</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation - metabolism</subject><subject>Interleukin-18 - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Labor, Obstetric - metabolism</subject><subject>mRNA</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>NLRP3</subject><subject>Nod1 protein</subject><subject>Nod1 Signaling Adaptor Protein - metabolism</subject><subject>NOD2 protein</subject><subject>Oligomerization</subject><subject>Parturition</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Pyrin protein</subject><subject>sterile inflammation</subject><subject>Young Adult</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2KqnyUQ_9AFYlLOQTGju04F6QV4mPRSpVaOFuT7LhklcRbO1vEv8clgAAJX8aaefRoRi9j3zgc8fSOcdUecSElfGI7XAPkYKpyK_1B6ryUYLbZbowrgNQvyi9sW-hKiULzHWZm2S_fUeZ8yMZbyuaD67DvMfqesnbIfq_9MOJAfhOzBdaJwjG7ptB_ZZ8ddpH2n-oeuzk_uz69zBc_L-ans0XeKKggF0XJlSuVFITcOOUKTsuqIRRlXRegEEunZLlEqZCE1IaWxtSggItGoXPFHjuZvOtN3dOyoWEM2Nl1aHsM99Zja99OhvbW_vH_bFJoATwJfjwJgv-7oTjavo0Ndd10leVGaK25KFRCD96hK78JQzrPCih0VRlQMlGHE9UEH2Mg97IMB_s_D5vysI95JPb76-1fyOcAEnA8AXdtR_cfm-zsaj4pHwAEkpL2</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Romero, Roberto</creator><creator>Xu, Yi</creator><creator>Plazyo, Olesya</creator><creator>Chaemsaithong, Piya</creator><creator>Chaiworapongsa, Tinnakorn</creator><creator>Unkel, Ronald</creator><creator>Than, Nandor Gabor</creator><creator>Chiang, Po Jen</creator><creator>Dong, Zhong</creator><creator>Xu, Zhonghui</creator><creator>Tarca, Adi L.</creator><creator>Abrahams, Vikki M.</creator><creator>Hassan, Sonia S.</creator><creator>Yeo, Lami</creator><creator>Gomez‐Lopez, Nardhy</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201806</creationdate><title>A Role for the Inflammasome in Spontaneous Labor at Term</title><author>Romero, Roberto ; Xu, Yi ; Plazyo, Olesya ; Chaemsaithong, Piya ; Chaiworapongsa, Tinnakorn ; Unkel, Ronald ; Than, Nandor Gabor ; Chiang, Po Jen ; Dong, Zhong ; Xu, Zhonghui ; Tarca, Adi L. ; Abrahams, Vikki M. ; Hassan, Sonia S. ; Yeo, Lami ; Gomez‐Lopez, Nardhy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5090-23715f7542ea18f5f31ed9cea27bb305aa7f547da45ae2468ed88b05012c5aff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Amnion - metabolism</topic><topic>Caspase</topic><topic>Caspase 1 - metabolism</topic><topic>caspase‐1</topic><topic>chorioamniotic membranes</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Humans</topic><topic>IL-1β</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Inflammasomes</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation - metabolism</topic><topic>Interleukin-18 - metabolism</topic><topic>Interleukin-1beta - metabolism</topic><topic>Labor, Obstetric - metabolism</topic><topic>mRNA</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</topic><topic>NLRP3</topic><topic>Nod1 protein</topic><topic>Nod1 Signaling Adaptor Protein - metabolism</topic><topic>NOD2 protein</topic><topic>Oligomerization</topic><topic>Parturition</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Pyrin protein</topic><topic>sterile inflammation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romero, Roberto</creatorcontrib><creatorcontrib>Xu, Yi</creatorcontrib><creatorcontrib>Plazyo, Olesya</creatorcontrib><creatorcontrib>Chaemsaithong, Piya</creatorcontrib><creatorcontrib>Chaiworapongsa, Tinnakorn</creatorcontrib><creatorcontrib>Unkel, Ronald</creatorcontrib><creatorcontrib>Than, Nandor Gabor</creatorcontrib><creatorcontrib>Chiang, Po Jen</creatorcontrib><creatorcontrib>Dong, Zhong</creatorcontrib><creatorcontrib>Xu, Zhonghui</creatorcontrib><creatorcontrib>Tarca, Adi L.</creatorcontrib><creatorcontrib>Abrahams, Vikki M.</creatorcontrib><creatorcontrib>Hassan, Sonia S.</creatorcontrib><creatorcontrib>Yeo, Lami</creatorcontrib><creatorcontrib>Gomez‐Lopez, Nardhy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romero, Roberto</au><au>Xu, Yi</au><au>Plazyo, Olesya</au><au>Chaemsaithong, Piya</au><au>Chaiworapongsa, Tinnakorn</au><au>Unkel, Ronald</au><au>Than, Nandor Gabor</au><au>Chiang, Po Jen</au><au>Dong, Zhong</au><au>Xu, Zhonghui</au><au>Tarca, Adi L.</au><au>Abrahams, Vikki M.</au><au>Hassan, Sonia S.</au><au>Yeo, Lami</au><au>Gomez‐Lopez, Nardhy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Role for the Inflammasome in Spontaneous Labor at Term</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>79</volume><issue>6</issue><spage>e12440</spage><epage>n/a</epage><pages>e12440-n/a</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
Inflammasomes are signaling platforms that, upon sensing pathogens and sterile stressors, mediate the release of mature forms of interleukin (IL)‐1β and IL‐18. The aims of this study were to determine (i) the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term, (ii) whether there are changes in the inflammasome components associated with the activation of caspase‐1 and caspase‐4, and (iii) whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
Method of study
Chorioamniotic membranes were collected from women at term with and without spontaneous labor. mRNA abundance and protein concentrations of inflammasome components, nucleotide‐binding oligomerization domain‐containing (NOD)1 and NOD2 proteins, caspase‐1, caspase‐4, IL‐1β, and IL‐18 were quantified by qRT‐PCR (n = 28–29 each), ELISA (n = 10 each) or immunoblotting (n = 8 each), and immunohistochemistry (n = 10 each). Active caspase‐1 and caspase‐4, as well as mature IL‐18, were determined by immunoblotting (n = 4 each), and pro‐ and mature forms of IL‐1β were determined by ELISA (n = 4–7 each).
Results
Inflammasome components and NOD proteins were expressed in the chorioamniotic membranes obtained from women at term. The chorioamniotic membranes from women who underwent labor had (i) higher concentrations of NLRP3 (NOD‐like receptor family, pyrin domain‐containing protein 3) and NOD1 protein, (ii) greater immunoreactivity for caspase‐1 and caspase‐4, (iii) a greater quantity of the active form of caspase‐1 (p20), and (iv) higher mRNA abundance and protein concentrations of pro‐ and mature IL‐1β. However, mRNA abundance and protein concentrations of the mature form of IL‐18 were not increased in tissues from women who underwent labor at term.
Conclusions
Spontaneous labor at term is characterized by the expression of inflammasome components, which may participate in the activation of caspase‐1 and lead to the cleavage and release of mature IL‐1β by the chorioamniotic membranes. These results support the participation of the inflammasome in the mechanisms responsible for spontaneous parturition at term.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26952361</pmid><doi>10.1111/aji.12440</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2018-06, Vol.79 (6), p.e12440-n/a |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5016201 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Amnion - metabolism Caspase Caspase 1 - metabolism caspase‐1 chorioamniotic membranes Enzyme-linked immunosorbent assay Female Humans IL-1β Immunoblotting Immunohistochemistry Inflammasomes Inflammasomes - metabolism Inflammation - metabolism Interleukin-18 - metabolism Interleukin-1beta - metabolism Labor, Obstetric - metabolism mRNA NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Nod1 protein Nod1 Signaling Adaptor Protein - metabolism NOD2 protein Oligomerization Parturition Pregnancy Proteins Pyrin protein sterile inflammation Young Adult |
| title | A Role for the Inflammasome in Spontaneous Labor at Term |
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