Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells

Long noncoding RNAs (lncRNA) have been associated with the development of cancer. However, the interplay between lncRNAs and androgen receptor (AR) signaling in prostate cancer is still unclear. Here, we identified lncRNAs induced by androgen in AR-positive prostate cancer cells, where induction was...

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Veröffentlicht in:	The Journal of biological chemistry 2016-08, Vol.291 (34), p.17861-17880
Hauptverfasser:	Misawa, Aya, Takayama, Ken-ichi, Urano, Tomohiko, Inoue, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen androgen receptor Androgens - pharmacology apoptosis Apoptosis - drug effects Cell Line, Tumor Epigenesis, Genetic - drug effects Epigenesis, Genetic - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Gene Regulation Humans long noncoding RNA (lncRNA) Male Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics prostate cancer Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Receptors, Androgen - biosynthesis Receptors, Androgen - genetics RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Signal Transduction - drug effects Signal Transduction - genetics TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - genetics Up-Regulation - drug effects Up-Regulation - genetics
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