Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia

Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia

Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess any subclinical renal injury in G6PD children. Sixty children were included. Thirty G6PD deficiency anemia children were enr...

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Veröffentlicht in:Mediterranean journal of hematology and infectious diseases 2016-08, Vol.8 (1), p.e2016038-e2016038
Hauptverfasser: Abdel Hakeem, Gehan Lotfy, Abdel Naeem, Emad Allam, Swelam, Salwa Hussein, El Morsi Aboul Fotoh, Laila, El Mazary, Abdel Azeem Mohamed, Abdel Fadil, Ashraf Mohamed, Abdel Hafez, Asmaa Hosny
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container_title Mediterranean journal of hematology and infectious diseases
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creator Abdel Hakeem, Gehan Lotfy
Abdel Naeem, Emad Allam
Swelam, Salwa Hussein
El Morsi Aboul Fotoh, Laila
El Mazary, Abdel Azeem Mohamed
Abdel Fadil, Ashraf Mohamed
Abdel Hafez, Asmaa Hosny
description Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is associated with intravascular hemolysis. The freely filtered hemoglobin can damage the kidney. We aimed to assess any subclinical renal injury in G6PD children. Sixty children were included. Thirty G6PD deficiency anemia children were enrolled during the acute hemolytic crisis and after the hemolytic episode had elapsed. Another thirty healthy children were included as controls. Serum cystatin C, creatinine levels, and urinary albumin/creatinine (A/C) ratio were measured, and the glomerular filtration rate (GFR) was calculated. Significantly higher urinary A/C ratio (p=0.001,0.002 respectively) and lower GFR (p=0.001 for both) were found during hemolysis and after the hemolytic episode compared to the controls. Also, significant higher serum cystatin C (p=0.001), creatinine (p=0.05) and A/C (p= 0.001) ratio and insignificant lower GFR (p=0.3) during acute hemolytic crisis compared to the same children after the hemolytic episode subsided. G6PD deficiency anemia is associated with a variable degree of acute renal injury during acute hemolytic episodes which may persist after elapsing of the hemolytic crises.
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title Detection of Occult Acute Kidney Injury in Glucose-6-Phosphate Dehydrogenase Deficiency Anemia
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