Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States
OBJECTIVE:HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factorsHIV population demographic structure (e.g. age distribution), general population (background) cancer rates, and HIV-associated relative risks. We asses...
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| Veröffentlicht in: | AIDS (London) 2014-03, Vol.28 (6), p.881-890 |
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| creator | Robbins, Hilary A Shiels, Meredith S Pfeiffer, Ruth M Engels, Eric A |
| description | OBJECTIVE:HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factorsHIV population demographic structure (e.g. age distribution), general population (background) cancer rates, and HIV-associated relative risks. We assessed the contributions of these factors to time trends for 10 cancers during 1996–2010.
DESIGN:Population-based registry linkage study.
METHODS:We applied Poisson models to data from the U.S. HIV/AIDS Cancer Match Study to estimate annual percentage changes (APCs) in incidence rates of AIDS-defining cancers [ADCsKaposi sarcoma, non-Hodgkin lymphoma (NHL), and cervical cancer] and seven non-AIDS-defining cancers (NADCs). We evaluated HIV-infected cancer trends with and without adjustment for demographics, trends in background rates, and trends in standardized incidence ratios (SIRs, to capture relative risk).
RESULTS:Cancer rates among HIV-infected people rose over time for anal (APC 3.8%), liver (8.5%), and prostate (9.8%) cancers, but declined for Kaposi sarcoma (1996–2000−29.3%; 2000–2010−7.8%), NHL (1996–2003−15.7%; 2003–2010−5.5%), cervical cancer (−11.1%), Hodgkin lymphoma (−4.0%), and lung cancer (−2.8%). Breast and colorectal cancer incidence did not change over time. Based on comparison to adjusted models, changing demographics contributed to trends for Kaposi sarcoma and breast, colorectal, liver, lung, and prostate cancers (all P |
| doi_str_mv | 10.1097/QAD.0000000000000163 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5015650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1506797146</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5863-e79bc4d1a54aa468d54f13b5f418a7cf8b9a29b76e373bb4f9cd918e089745803</originalsourceid><addsrcrecordid>eNqFkUFvFCEYhonR2LX6D4zhYuJlKiwwwMWkaatt0sQYrVfCMN_sogyswNj4753JrrV6UC4QeL43L3kQek7JCSVavv5wen5C7i_asgdoRblkjRCSPkQrsm51o5kkR-hJKV9mRhClHqOjNWfzmYsV6i52vofRp5A23mGXYs2-m6pPseCacAYHsWJno4OMa4bYF2zHFDf48upz4-MArkKPd5B2AbCPuG4B30S_XH6stkJ5ih4NNhR4dtiP0c3bi09nl831-3dXZ6fXjROqZQ1I3TneUyu4tbxVveADZZ0YOFVWukF12q51J1tgknUdH7TrNVVAlJZcKMKO0Zt97m7qRuiX3tkGs8t-tPmHSdabP1-i35pN-m4EoaIVS8CrQ0BO3yYo1Yy-OAjBRkhTMVS2Qqu1Zur_qCCt1JLydkb5HnU5lZJhuGtEiVlMmtmk-dvkPPbi_m_uhn6pm4GXB8AWZ8OQZ0W-_OYUJ4ypparac7cpVMjla5huIZst2FC3_-7wE7vuuDs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506797146</pqid></control><display><type>article</type><title>Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Robbins, Hilary A ; Shiels, Meredith S ; Pfeiffer, Ruth M ; Engels, Eric A</creator><creatorcontrib>Robbins, Hilary A ; Shiels, Meredith S ; Pfeiffer, Ruth M ; Engels, Eric A</creatorcontrib><description>OBJECTIVE:HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factorsHIV population demographic structure (e.g. age distribution), general population (background) cancer rates, and HIV-associated relative risks. We assessed the contributions of these factors to time trends for 10 cancers during 1996–2010.
DESIGN:Population-based registry linkage study.
METHODS:We applied Poisson models to data from the U.S. HIV/AIDS Cancer Match Study to estimate annual percentage changes (APCs) in incidence rates of AIDS-defining cancers [ADCsKaposi sarcoma, non-Hodgkin lymphoma (NHL), and cervical cancer] and seven non-AIDS-defining cancers (NADCs). We evaluated HIV-infected cancer trends with and without adjustment for demographics, trends in background rates, and trends in standardized incidence ratios (SIRs, to capture relative risk).
RESULTS:Cancer rates among HIV-infected people rose over time for anal (APC 3.8%), liver (8.5%), and prostate (9.8%) cancers, but declined for Kaposi sarcoma (1996–2000−29.3%; 2000–2010−7.8%), NHL (1996–2003−15.7%; 2003–2010−5.5%), cervical cancer (−11.1%), Hodgkin lymphoma (−4.0%), and lung cancer (−2.8%). Breast and colorectal cancer incidence did not change over time. Based on comparison to adjusted models, changing demographics contributed to trends for Kaposi sarcoma and breast, colorectal, liver, lung, and prostate cancers (all P < 0.01). Trends in background rates were notable for liver (APC 5.6%) and lung (−3.2%) cancers. SIRs declined for ADCs, Hodgkin lymphoma (APC −3.2%), and lung cancer (−4.4%).
CONCLUSION:Demographic shifts influenced several cancer trends among HIV-infected individuals. Falling relative risks largely explained ADC declines, while background incidence contributed to some NADC trends.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000000163</identifier><identifier>PMID: 24300545</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; HIV Infections - complications ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Incidence ; Infant ; Infectious diseases ; Lentivirus ; Male ; Medical sciences ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasms - epidemiology ; Retroviridae ; Tumors ; United States - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>AIDS (London), 2014-03, Vol.28 (6), p.881-890</ispartof><rights>2014 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5863-e79bc4d1a54aa468d54f13b5f418a7cf8b9a29b76e373bb4f9cd918e089745803</citedby><cites>FETCH-LOGICAL-c5863-e79bc4d1a54aa468d54f13b5f418a7cf8b9a29b76e373bb4f9cd918e089745803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28403388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24300545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robbins, Hilary A</creatorcontrib><creatorcontrib>Shiels, Meredith S</creatorcontrib><creatorcontrib>Pfeiffer, Ruth M</creatorcontrib><creatorcontrib>Engels, Eric A</creatorcontrib><title>Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>OBJECTIVE:HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factorsHIV population demographic structure (e.g. age distribution), general population (background) cancer rates, and HIV-associated relative risks. We assessed the contributions of these factors to time trends for 10 cancers during 1996–2010.
DESIGN:Population-based registry linkage study.
METHODS:We applied Poisson models to data from the U.S. HIV/AIDS Cancer Match Study to estimate annual percentage changes (APCs) in incidence rates of AIDS-defining cancers [ADCsKaposi sarcoma, non-Hodgkin lymphoma (NHL), and cervical cancer] and seven non-AIDS-defining cancers (NADCs). We evaluated HIV-infected cancer trends with and without adjustment for demographics, trends in background rates, and trends in standardized incidence ratios (SIRs, to capture relative risk).
RESULTS:Cancer rates among HIV-infected people rose over time for anal (APC 3.8%), liver (8.5%), and prostate (9.8%) cancers, but declined for Kaposi sarcoma (1996–2000−29.3%; 2000–2010−7.8%), NHL (1996–2003−15.7%; 2003–2010−5.5%), cervical cancer (−11.1%), Hodgkin lymphoma (−4.0%), and lung cancer (−2.8%). Breast and colorectal cancer incidence did not change over time. Based on comparison to adjusted models, changing demographics contributed to trends for Kaposi sarcoma and breast, colorectal, liver, lung, and prostate cancers (all P < 0.01). Trends in background rates were notable for liver (APC 5.6%) and lung (−3.2%) cancers. SIRs declined for ADCs, Hodgkin lymphoma (APC −3.2%), and lung cancer (−4.4%).
CONCLUSION:Demographic shifts influenced several cancer trends among HIV-infected individuals. Falling relative risks largely explained ADC declines, while background incidence contributed to some NADC trends.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV Infections - complications</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Lentivirus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasms - epidemiology</subject><subject>Retroviridae</subject><subject>Tumors</subject><subject>United States - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Young Adult</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEYhonR2LX6D4zhYuJlKiwwwMWkaatt0sQYrVfCMN_sogyswNj4753JrrV6UC4QeL43L3kQek7JCSVavv5wen5C7i_asgdoRblkjRCSPkQrsm51o5kkR-hJKV9mRhClHqOjNWfzmYsV6i52vofRp5A23mGXYs2-m6pPseCacAYHsWJno4OMa4bYF2zHFDf48upz4-MArkKPd5B2AbCPuG4B30S_XH6stkJ5ih4NNhR4dtiP0c3bi09nl831-3dXZ6fXjROqZQ1I3TneUyu4tbxVveADZZ0YOFVWukF12q51J1tgknUdH7TrNVVAlJZcKMKO0Zt97m7qRuiX3tkGs8t-tPmHSdabP1-i35pN-m4EoaIVS8CrQ0BO3yYo1Yy-OAjBRkhTMVS2Qqu1Zur_qCCt1JLydkb5HnU5lZJhuGtEiVlMmtmk-dvkPPbi_m_uhn6pm4GXB8AWZ8OQZ0W-_OYUJ4ypparac7cpVMjla5huIZst2FC3_-7wE7vuuDs</recordid><startdate>20140327</startdate><enddate>20140327</enddate><creator>Robbins, Hilary A</creator><creator>Shiels, Meredith S</creator><creator>Pfeiffer, Ruth M</creator><creator>Engels, Eric A</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7T5</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140327</creationdate><title>Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States</title><author>Robbins, Hilary A ; Shiels, Meredith S ; Pfeiffer, Ruth M ; Engels, Eric A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5863-e79bc4d1a54aa468d54f13b5f418a7cf8b9a29b76e373bb4f9cd918e089745803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV Infections - complications</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Lentivirus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasms - epidemiology</topic><topic>Retroviridae</topic><topic>Tumors</topic><topic>United States - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robbins, Hilary A</creatorcontrib><creatorcontrib>Shiels, Meredith S</creatorcontrib><creatorcontrib>Pfeiffer, Ruth M</creatorcontrib><creatorcontrib>Engels, Eric A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robbins, Hilary A</au><au>Shiels, Meredith S</au><au>Pfeiffer, Ruth M</au><au>Engels, Eric A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2014-03-27</date><risdate>2014</risdate><volume>28</volume><issue>6</issue><spage>881</spage><epage>890</epage><pages>881-890</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>OBJECTIVE:HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factorsHIV population demographic structure (e.g. age distribution), general population (background) cancer rates, and HIV-associated relative risks. We assessed the contributions of these factors to time trends for 10 cancers during 1996–2010.
DESIGN:Population-based registry linkage study.
METHODS:We applied Poisson models to data from the U.S. HIV/AIDS Cancer Match Study to estimate annual percentage changes (APCs) in incidence rates of AIDS-defining cancers [ADCsKaposi sarcoma, non-Hodgkin lymphoma (NHL), and cervical cancer] and seven non-AIDS-defining cancers (NADCs). We evaluated HIV-infected cancer trends with and without adjustment for demographics, trends in background rates, and trends in standardized incidence ratios (SIRs, to capture relative risk).
RESULTS:Cancer rates among HIV-infected people rose over time for anal (APC 3.8%), liver (8.5%), and prostate (9.8%) cancers, but declined for Kaposi sarcoma (1996–2000−29.3%; 2000–2010−7.8%), NHL (1996–2003−15.7%; 2003–2010−5.5%), cervical cancer (−11.1%), Hodgkin lymphoma (−4.0%), and lung cancer (−2.8%). Breast and colorectal cancer incidence did not change over time. Based on comparison to adjusted models, changing demographics contributed to trends for Kaposi sarcoma and breast, colorectal, liver, lung, and prostate cancers (all P < 0.01). Trends in background rates were notable for liver (APC 5.6%) and lung (−3.2%) cancers. SIRs declined for ADCs, Hodgkin lymphoma (APC −3.2%), and lung cancer (−4.4%).
CONCLUSION:Demographic shifts influenced several cancer trends among HIV-infected individuals. Falling relative risks largely explained ADC declines, while background incidence contributed to some NADC trends.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>24300545</pmid><doi>10.1097/QAD.0000000000000163</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Child, Preschool Female HIV Infections - complications Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Incidence Infant Infectious diseases Lentivirus Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - epidemiology Retroviridae Tumors United States - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| title | Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States |
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