Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants...

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Veröffentlicht in:	Scientific reports 2016-09, Vol.6 (1), p.32606-32606, Article 32606
Hauptverfasser:	Cetinbas, Naniye Mallı, Sudderth, Jessica, Harris, Robert C., Cebeci, Aysun, Negri, Gian L., Yılmaz, Ömer H., DeBerardinis, Ralph J., Sorensen, Poul H.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/31 631/45/320 631/80/86/2369 82/58 Addictions Antioxidants Cancer Cell death Glucose Glutamine Glutathione Humanities and Social Sciences multidisciplinary NADP Oxidants Oxidizing agents Pyruvic acid Reactive oxygen species Science Starvation Survival Tricarboxylic acid cycle Tumor cell lines
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