Change in the Molecular Dimension of a RAGE-Ligand Complex Triggers RAGE Signaling

The weak oligomerization exhibited by many transmembrane receptors has a profound effect on signal transduction. The phenomenon is difficult to characterize structurally due to the large sizes of and transient interactions between monomers. The receptor for advanced glycation end products (RAGE), a...

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Veröffentlicht in:	Structure (London) 2016-09, Vol.24 (9), p.1509-1522
Hauptverfasser:	Xue, Jing, Manigrasso, Michaele, Scalabrin, Matteo, Rai, Vivek, Reverdatto, Sergey, Burz, David S., Fabris, Daniele, Schmidt, Ann Marie, Shekhtman, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Antigens, Neoplasm - chemistry Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites cancer Cross-Linking Reagents - chemistry diabetes diaphanous 1 Gene Expression Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans hybrid method of structure determination inflammation Ligands Luminescent Proteins - genetics Luminescent Proteins - metabolism Maleimides - chemistry mass spectrometry Mitogen-Activated Protein Kinases - chemistry Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Molecular Docking Simulation NMR spectroscopy Nuclear Magnetic Resonance, Biomolecular pattern recognition Protein Binding Protein Interaction Domains and Motifs Protein Structure, Secondary RAGE receptor for advanced glycation end products Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism segmental labeling Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Thermodynamics
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