Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes

Visual impairment due to glaucoma currently impacts 70 million people worldwide. While disease progression can be slowed or stopped with effective lowering of intraocular pressure, current medical treatments are often inadequate. Fortunately, three new classes of therapeutics that target the disease...

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Veröffentlicht in:	European journal of pharmacology 2016-09, Vol.787, p.20-31
Hauptverfasser:	Li, Guorong, Mukherjee, Dibyendu, Navarro, Iris, Ashpole, Nicole E., Sherwood, Joseph M., Chang, Jinlong, Overby, Darryl R., Yuan, Fan, Gonzalez, Pedro, Kopczynski, Casey C., Farsiu, Sina, Stamer, W. Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor - drug effects Aqueous Humor - metabolism Aqueous Humor - physiology Benzoates - administration & dosage Benzoates - pharmacology beta-Alanine - administration & dosage beta-Alanine - analogs & derivatives beta-Alanine - pharmacology Conventional outflow Eye - drug effects Eye - metabolism Fluorescent Dyes - metabolism Image Processing, Computer-Assisted Intraocular Pressure - drug effects Mice Ocular hypertension Ocular Physiological Phenomena - drug effects Rho kinase inhibitor Schlemm’s canal Tomography, Optical Coherence Trabecular meshwork Trabecular Meshwork - drug effects Trabecular Meshwork - metabolism Trabecular Meshwork - physiology
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