Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption
Background/Objectives: Prader–Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison w...
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| Veröffentlicht in: | International Journal of Obesity 2016-09, Vol.40 (9), p.1360-1368 |
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| creator | Reinhardt, M Parigi, A D Chen, K Reiman, E M Thiyyagura, P Krakoff, J Hohenadel, M G Le, D S N T Weise, C M |
| description | Background/Objectives:
Prader–Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.
Subjects/Methods:
This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3±10.0%) and seven controls (7 men; body fat 28.8±7.6%), matched for percentage body fat. H
2
15
O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity.
Results:
Compared with obese controls, PWS showed altered (
P |
| doi_str_mv | 10.1038/ijo.2016.75 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5014561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A462578356</galeid><sourcerecordid>A462578356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c636t-b94a5ccc8b19b567ca38eede632a0402d47b1ca0b51354dee72ac535a559c2593</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7rh65b0UBBG0Y75O0t4Iw_oJC3qheBnS9HQmQ9uMSbu4d_4H_6G_xNRZ11lZVHKRkPOcNx_vm2X3KVlSwstnbuuXjFC5VHAjW1ChZAGiUjezBeFEFQQkHGV3YtwSQgAIu50dMUUZZaJcZO4FGju6MzM6P-S-zccN5h22Y974EH1nRgymy3cB2-CHMS2tDyN-yd2Qvw-mwfD967dPrutcHs-HJvgec9OmprzHn_AQp343i9_NbrWmi3jvYj7OPr56-eHkTXH67vXbk9VpYSWXY1FXwoC1tqxpVYNU1vASsUHJmSGCsEaomlpDaqAcRIOomLHAwQBUlkHFj7Pne93dVPfYWBzG9AK9C6434Vx74_TVyuA2eu3PNBAqQNIk8PhCIPjPE8ZR9y5a7DozoJ-ipiVTFVOMq_9AqQJQgszXevgHuvVTGNJPaCZ5RTmnSv2NSlqylBUV8je1Nh1qN7Q-PcTOR-uVkAxUyWGmltdQaTTYu2QMti7tX2l4dNCwSf6NmxSBaXYv6pWEOT8VEf8CDxWf7EEbfIwpQ5c2UKLn8OoUXj2HVytI9IND5y7ZX2lNwNM9EFNpWGM4-J1r9H4AZ_v39A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1816869146</pqid></control><display><type>article</type><title>Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature</source><creator>Reinhardt, M ; Parigi, A D ; Chen, K ; Reiman, E M ; Thiyyagura, P ; Krakoff, J ; Hohenadel, M G ; Le, D S N T ; Weise, C M</creator><creatorcontrib>Reinhardt, M ; Parigi, A D ; Chen, K ; Reiman, E M ; Thiyyagura, P ; Krakoff, J ; Hohenadel, M G ; Le, D S N T ; Weise, C M</creatorcontrib><description>Background/Objectives:
Prader–Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.
Subjects/Methods:
This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3±10.0%) and seven controls (7 men; body fat 28.8±7.6%), matched for percentage body fat. H
2
15
O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity.
Results:
Compared with obese controls, PWS showed altered (
P
<0.05 family-wise error cluster-level corrected; voxelwise
P
<0.001) rCBF before and after meal consumption in multiple brain regions. There was a significant differential rCBF response within the left DLPFC after meal ingestion with decreases in DLPFC rCBF in PWS; in controls, DLPFC rCBF tended to remain unchanged. In more liberal analyses (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.005), rCBF of the right orbitofrontal cortex (OFC) increased in PWS and decreased in controls. In PWS, ΔrCBF of the right OFC was associated with changes in appetite ratings.
Conclusions:
The pathophysiology of eating behavior in PWS is characterized by a paradoxical meal-induced deactivation of the left DLPFC and activation in the right OFC, brain regions implicated in the central regulation of eating behavior.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2016.75</identifier><identifier>PMID: 27121248</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/78 ; 631/378/1457/1945 ; 631/378/1488 ; 631/378/1488/393 ; 692/699/2743/393 ; Adult ; Appetite ; Appetite (Psychophysiology) ; Blood flow ; Body fat ; Brain ; Brain Mapping ; Brain research ; Cerebral blood flow ; Cerebrovascular Circulation ; Clusters ; Deactivation ; Diabetes ; Eating ; Eating behavior ; Epidemiology ; Error analysis ; Error correction ; Feeding Behavior ; Female ; Food ; Food consumption ; Food habits ; Functional Neuroimaging ; Genetic disorders ; Health aspects ; Health Promotion and Disease Prevention ; Humans ; Hunger ; Ingestion ; Internal Medicine ; Magnetic Resonance Imaging ; Male ; Meals ; Medical imaging ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Neuroimaging ; Obesity ; original-article ; Physiological aspects ; Positron emission ; Positron emission tomography ; Postprandial Period ; Prader-Willi syndrome ; Prader-Willi Syndrome - epidemiology ; Prader-Willi Syndrome - physiopathology ; Prefrontal cortex ; Prefrontal Cortex - physiopathology ; Psychological aspects ; Public Health ; Reward ; Satiation ; Satiety ; Satiety Response ; Tomography ; Womens health</subject><ispartof>International Journal of Obesity, 2016-09, Vol.40 (9), p.1360-1368</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature 2016</rights><rights>COPYRIGHT 2016 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2016</rights><rights>Macmillan Publishers Limited, part of Springer Nature 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c636t-b94a5ccc8b19b567ca38eede632a0402d47b1ca0b51354dee72ac535a559c2593</citedby><cites>FETCH-LOGICAL-c636t-b94a5ccc8b19b567ca38eede632a0402d47b1ca0b51354dee72ac535a559c2593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2016.75$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2016.75$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27121248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reinhardt, M</creatorcontrib><creatorcontrib>Parigi, A D</creatorcontrib><creatorcontrib>Chen, K</creatorcontrib><creatorcontrib>Reiman, E M</creatorcontrib><creatorcontrib>Thiyyagura, P</creatorcontrib><creatorcontrib>Krakoff, J</creatorcontrib><creatorcontrib>Hohenadel, M G</creatorcontrib><creatorcontrib>Le, D S N T</creatorcontrib><creatorcontrib>Weise, C M</creatorcontrib><title>Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background/Objectives:
Prader–Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.
Subjects/Methods:
This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3±10.0%) and seven controls (7 men; body fat 28.8±7.6%), matched for percentage body fat. H
2
15
O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity.
Results:
Compared with obese controls, PWS showed altered (
P
<0.05 family-wise error cluster-level corrected; voxelwise
P
<0.001) rCBF before and after meal consumption in multiple brain regions. There was a significant differential rCBF response within the left DLPFC after meal ingestion with decreases in DLPFC rCBF in PWS; in controls, DLPFC rCBF tended to remain unchanged. In more liberal analyses (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.005), rCBF of the right orbitofrontal cortex (OFC) increased in PWS and decreased in controls. In PWS, ΔrCBF of the right OFC was associated with changes in appetite ratings.
Conclusions:
The pathophysiology of eating behavior in PWS is characterized by a paradoxical meal-induced deactivation of the left DLPFC and activation in the right OFC, brain regions implicated in the central regulation of eating behavior.</description><subject>59/78</subject><subject>631/378/1457/1945</subject><subject>631/378/1488</subject><subject>631/378/1488/393</subject><subject>692/699/2743/393</subject><subject>Adult</subject><subject>Appetite</subject><subject>Appetite (Psychophysiology)</subject><subject>Blood flow</subject><subject>Body fat</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Clusters</subject><subject>Deactivation</subject><subject>Diabetes</subject><subject>Eating</subject><subject>Eating behavior</subject><subject>Epidemiology</subject><subject>Error analysis</subject><subject>Error correction</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>Food consumption</subject><subject>Food habits</subject><subject>Functional Neuroimaging</subject><subject>Genetic disorders</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Hunger</subject><subject>Ingestion</subject><subject>Internal Medicine</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Meals</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Neuroimaging</subject><subject>Obesity</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Postprandial Period</subject><subject>Prader-Willi syndrome</subject><subject>Prader-Willi Syndrome - epidemiology</subject><subject>Prader-Willi Syndrome - physiopathology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychological aspects</subject><subject>Public Health</subject><subject>Reward</subject><subject>Satiation</subject><subject>Satiety</subject><subject>Satiety Response</subject><subject>Tomography</subject><subject>Womens health</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl2L1DAUhoso7rh65b0UBBG0Y75O0t4Iw_oJC3qheBnS9HQmQ9uMSbu4d_4H_6G_xNRZ11lZVHKRkPOcNx_vm2X3KVlSwstnbuuXjFC5VHAjW1ChZAGiUjezBeFEFQQkHGV3YtwSQgAIu50dMUUZZaJcZO4FGju6MzM6P-S-zccN5h22Y974EH1nRgymy3cB2-CHMS2tDyN-yd2Qvw-mwfD967dPrutcHs-HJvgec9OmprzHn_AQp343i9_NbrWmi3jvYj7OPr56-eHkTXH67vXbk9VpYSWXY1FXwoC1tqxpVYNU1vASsUHJmSGCsEaomlpDaqAcRIOomLHAwQBUlkHFj7Pne93dVPfYWBzG9AK9C6434Vx74_TVyuA2eu3PNBAqQNIk8PhCIPjPE8ZR9y5a7DozoJ-ipiVTFVOMq_9AqQJQgszXevgHuvVTGNJPaCZ5RTmnSv2NSlqylBUV8je1Nh1qN7Q-PcTOR-uVkAxUyWGmltdQaTTYu2QMti7tX2l4dNCwSf6NmxSBaXYv6pWEOT8VEf8CDxWf7EEbfIwpQ5c2UKLn8OoUXj2HVytI9IND5y7ZX2lNwNM9EFNpWGM4-J1r9H4AZ_v39A</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Reinhardt, M</creator><creator>Parigi, A D</creator><creator>Chen, K</creator><creator>Reiman, E M</creator><creator>Thiyyagura, P</creator><creator>Krakoff, J</creator><creator>Hohenadel, M G</creator><creator>Le, D S N T</creator><creator>Weise, C M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption</title><author>Reinhardt, M ; Parigi, A D ; Chen, K ; Reiman, E M ; Thiyyagura, P ; Krakoff, J ; Hohenadel, M G ; Le, D S N T ; Weise, C M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-b94a5ccc8b19b567ca38eede632a0402d47b1ca0b51354dee72ac535a559c2593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>59/78</topic><topic>631/378/1457/1945</topic><topic>631/378/1488</topic><topic>631/378/1488/393</topic><topic>692/699/2743/393</topic><topic>Adult</topic><topic>Appetite</topic><topic>Appetite (Psychophysiology)</topic><topic>Blood flow</topic><topic>Body fat</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Brain research</topic><topic>Cerebral blood flow</topic><topic>Cerebrovascular Circulation</topic><topic>Clusters</topic><topic>Deactivation</topic><topic>Diabetes</topic><topic>Eating</topic><topic>Eating behavior</topic><topic>Epidemiology</topic><topic>Error analysis</topic><topic>Error correction</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Food</topic><topic>Food consumption</topic><topic>Food habits</topic><topic>Functional Neuroimaging</topic><topic>Genetic disorders</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Hunger</topic><topic>Ingestion</topic><topic>Internal Medicine</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Meals</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Neuroimaging</topic><topic>Obesity</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Postprandial Period</topic><topic>Prader-Willi syndrome</topic><topic>Prader-Willi Syndrome - epidemiology</topic><topic>Prader-Willi Syndrome - physiopathology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychological aspects</topic><topic>Public Health</topic><topic>Reward</topic><topic>Satiation</topic><topic>Satiety</topic><topic>Satiety Response</topic><topic>Tomography</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reinhardt, M</creatorcontrib><creatorcontrib>Parigi, A D</creatorcontrib><creatorcontrib>Chen, K</creatorcontrib><creatorcontrib>Reiman, E M</creatorcontrib><creatorcontrib>Thiyyagura, P</creatorcontrib><creatorcontrib>Krakoff, J</creatorcontrib><creatorcontrib>Hohenadel, M G</creatorcontrib><creatorcontrib>Le, D S N T</creatorcontrib><creatorcontrib>Weise, C M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reinhardt, M</au><au>Parigi, A D</au><au>Chen, K</au><au>Reiman, E M</au><au>Thiyyagura, P</au><au>Krakoff, J</au><au>Hohenadel, M G</au><au>Le, D S N T</au><au>Weise, C M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>40</volume><issue>9</issue><spage>1360</spage><epage>1368</epage><pages>1360-1368</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background/Objectives:
Prader–Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.
Subjects/Methods:
This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3±10.0%) and seven controls (7 men; body fat 28.8±7.6%), matched for percentage body fat. H
2
15
O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity.
Results:
Compared with obese controls, PWS showed altered (
P
<0.05 family-wise error cluster-level corrected; voxelwise
P
<0.001) rCBF before and after meal consumption in multiple brain regions. There was a significant differential rCBF response within the left DLPFC after meal ingestion with decreases in DLPFC rCBF in PWS; in controls, DLPFC rCBF tended to remain unchanged. In more liberal analyses (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.005), rCBF of the right orbitofrontal cortex (OFC) increased in PWS and decreased in controls. In PWS, ΔrCBF of the right OFC was associated with changes in appetite ratings.
Conclusions:
The pathophysiology of eating behavior in PWS is characterized by a paradoxical meal-induced deactivation of the left DLPFC and activation in the right OFC, brain regions implicated in the central regulation of eating behavior.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27121248</pmid><doi>10.1038/ijo.2016.75</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2016-09, Vol.40 (9), p.1360-1368 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5014561 |
| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | 59/78 631/378/1457/1945 631/378/1488 631/378/1488/393 692/699/2743/393 Adult Appetite Appetite (Psychophysiology) Blood flow Body fat Brain Brain Mapping Brain research Cerebral blood flow Cerebrovascular Circulation Clusters Deactivation Diabetes Eating Eating behavior Epidemiology Error analysis Error correction Feeding Behavior Female Food Food consumption Food habits Functional Neuroimaging Genetic disorders Health aspects Health Promotion and Disease Prevention Humans Hunger Ingestion Internal Medicine Magnetic Resonance Imaging Male Meals Medical imaging Medicine Medicine & Public Health Metabolic Diseases Neuroimaging Obesity original-article Physiological aspects Positron emission Positron emission tomography Postprandial Period Prader-Willi syndrome Prader-Willi Syndrome - epidemiology Prader-Willi Syndrome - physiopathology Prefrontal cortex Prefrontal Cortex - physiopathology Psychological aspects Public Health Reward Satiation Satiety Satiety Response Tomography Womens health |
| title | Deactivation of the left dorsolateral prefrontal cortex in Prader–Willi syndrome after meal consumption |
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