Nonmuscle Myosin IIA Regulates Platelet Contractile Forces Through Rho Kinase and Myosin Light-Chain Kinase

Platelet contractile forces play a major role in clot retraction and help to hold hemostatic clots against the vessel wall. Platelet forces are produced by its cytoskeleton, which is composed of actin and nonmuscle myosin filaments. In this work, we studied the role of Rho kinase, myosin light-chain...

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Veröffentlicht in:	Journal of biomechanical engineering 2016-10, Vol.138 (10), p.1045061-1045064
Hauptverfasser:	Feghhi, Shirin, Tooley, Wes W, Sniadecki, Nathan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Blood Platelets - physiology Cells, Cultured Cytoskeleton - physiology Hemostasis - physiology Hemostatics Humans Inhibition Kinases Myosin Myosin-Light-Chain Kinase - metabolism Nonmuscle Myosin Type IIA - metabolism Phosphorylation Platelet Aggregation - physiology Platelets rho-Associated Kinases - metabolism Rock Stress, Mechanical Technical Brief
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