Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

Metabolic reprogramming, in which altered utilization of glucose and glutamine supports rapid growth, is a hallmark of most cancers. Mutations in the oncogenes KRAS and BRAF drive metabolic reprogramming through enhanced glucose uptake, but the broader impact of these mutations on pathways of carbon...

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Veröffentlicht in:	Molecular & cellular proteomics 2016-09, Vol.15 (9), p.2924-2938
Hauptverfasser:	Hutton, Josiah E., Wang, Xiaojing, Zimmerman, Lisa J., Slebos, Robbert J.C., Trenary, Irina A., Young, Jamey D., Li, Ming, Liebler, Daniel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthetic Pathways Cell Line, Tumor Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Gene Expression Regulation, Neoplastic Glucose - metabolism Humans Lactic Acid - metabolism Mutation Proteomics - methods Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics
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